PCGF6 Antibody, Biotin conjugated
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中文名稱：PCGF6兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA871612LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) PCGF6 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：MBLR antibody; Mel18 and Bmi1 like RING finger protein antibody; Mel18 and Bmi1-like RING finger antibody; Pcgf6 antibody; PCGF6_HUMAN antibody; Polycomb group RING finger protein 6 antibody; RING finger protein 134 antibody; RNF134 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Polycomb group RING finger protein 6 protein (9-70AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
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基因功能參考文獻：
- Pcgf6 acts as a master regulator to maintain embryonic stem cell identity. PMID: 27247273
- regulation by cell cycle-dependent phosphorylation PMID: 12167161
- Thus, we did not find evidence for uniquely interacting partner proteins using this approach, but did identify four new lamin A/C interactive partners PMID: 16248985
- Study shows that JARID1d and MBLR occupy human Engrailed 2 gene and regulate its expression and histone H3 lysine 4 methylation levels. PMID: 17320162
- MEL-18 bound to HSF2 inhibits its sumoylation by binding to and inhibiting the activity of UBC9 enzymes in the vicinity of HSF2. PMID: 18211895
- Mel-18 overexpression showed reduced glycogen synthase kinase-3beta phosphorylation, beta-catenin nuclear localization, T-cell factor/lymphoid enhancer factor promoter activity, and cyclin D1 mRNA level PMID: 18519679
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亞細胞定位：Nucleus.
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組織特異性：Ubiquitous.
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數(shù)據(jù)庫鏈接：
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