PBX3 Antibody
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中文名稱：PBX3兔多克隆抗體
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貨號：CSB-PA017507GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：PBX3
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別名：Homeobox protein PBX3 antibody; MGC134053 antibody; OTTHUMP00000064213 antibody; Pbx 3 antibody; Pbx3 antibody; PBX3_HUMAN antibody; Pre B cell leukemia homeobox 3 antibody; Pre B cell leukemia transcription factor 3 antibody; Pre-B-cell leukemia transcription factor 3 antibody; RP11 336P12.1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human PBX3
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.
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基因功能參考文獻：
- the present study indicates that PBX 3'UTR may induce inflammatory responses and sepsis via acting as a competing endogenous RNA for HMGB1. PMID: 29484406
- Results show that PBX3 expression is increased in both human glioma tissues and cell lines. Furthermore, silencing of PBX3 remarkably reduced glioma cell proliferation and induced apoptosis, while PBX3 overexpression dramatically increased glioma cell proliferation. Finally, PBX3 promoted glioma cell proliferation by modulating cell cycle progression. PMID: 28856521
- Silencing PBX3 inhibited the migratory and invasive capacities of glioma cells. PMID: 28124208
- miR-33a-3p suppressed the malignant phenotype while also inhibiting PBX3 expression in hepatocellular cancer PMID: 27285759
- Results found that PBX3 is epigenetically aberrant in leukemia stem cell maintenance of MLL-rearranged AML and is essential for leukemia development. PMID: 28411381
- results suggest that miR-144-3p suppresses GC progression by inhibiting EMT through targeting PBX3 PMID: 28111340
- Patients undergoing radical prostatectomy, with high levels of PBX3 mRNA, had improved prostate cancer specific survival compared to patients expressing low levels. PMID: 27273830
- Our findings collectively indicate that miR-320a inhibits cell proliferation and induces apoptosis in MM cells by directly targeting PBX3, supporting its utility as a novel and potential therapeutic agent for miRNA-based MM therapy. PMID: 27086852
- Studies implicate PBX3/MEIS1 interaction as a driver of cell transformation and leukemogenesis, and that this axis may play a critical role in the regulation of the core transcriptional programs activated in MLL-rearranged and HOX-overexpressing AML. PMID: 26747896
- let-7c, miR-200b, miR-222 and miR-424 target PBX3, which is necessary for the acquisition and maintenance of liver tumour-initiating cells properties. PMID: 26420065
- Pbx3 contributes to Hoxa9 leukemogenesis through stabilization of the Meis1 protein. PMID: 26130510
- PBX3 induces invasion and metastasis of colorectal caner cells partially through activation of the MAPK/ERK signaling pathway. PMID: 25561793
- An intermediate-risk group of acute myeloid leukemia patients compared to a group with a favorable risk reduces to a four-gene signature of HOXA6, HOXA9, PBX3 and MEIS1 by iterative analysis of independent platforms. PMID: 23539541
- matrigel invasion assay showed that PBX3 transfection also increased cell-invading ability PMID: 24375258
- Increased expression of PBX3 is associated with pilocytic astrocytoma. PMID: 23161775
- Collectively, our data suggest that PBX3 is a critical cofactor of HOXA9 in leukemogenesis. PMID: 23264595
- The Pbx3 Ala136Val variant is a modifier or risk allele for congenital heart defects. PMID: 22426282
- Data show that up-regulation of the HOXA7, HOXA9, HOXA11, and PBX3 resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable cytogenetically abnormal AML (CA-AML). PMID: 22251480
- PBX3 is up-regulated in prostate cancer and post- transcriptionally regulated by androgen through Let-7d. PMID: 21548940
- our results seem to discard the role of the previously described polymorphisms in SERPINE2, PPP6C and PBX3 in celiac disease susceptibility. PMID: 19626039
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亞細胞定位：Nucleus.
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蛋白家族：TALE/PBX homeobox family
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組織特異性：Ubiquitously expressed.
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數(shù)據(jù)庫鏈接：
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