PAX7 Antibody
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中文名稱：PAX7兔多克隆抗體
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貨號：CSB-PA891015
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA891015(PAX7 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：PAX7
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別名：FLJ37460 antibody; HUP1 antibody; OTTHUMP00000002534 antibody; Paired box 7 antibody; Paired box gene 7 antibody; Paired box homeotic gene 7 antibody; Paired box protein Pax-7 antibody; Paired domain gene 7 antibody; Paired domain gene HuP1 antibody; Pax7 antibody; PAX7 transcriptional factor antibody; PAX7/FKHR fusion gene, included antibody; PAX7_HUMAN antibody; PAX7B antibody; RGD1564360 antibody; RMS2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Fusion protein of Human PAX7
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻(xiàn)
- Isolation and Cultivation of Sterlet Myoblasts AM Aimaletdinov,/,2023
- Isolation, culturing and 3D bioprinting equine myoblasts A Aimaletdinov,Biological Communications,2022
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.
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基因功能參考文獻(xiàn)：
- Data suggest that paired box gene 7 protein (PAX7) target gene repression is a hallmark of facioscapulohumeral muscular dystrophy (FSHD) that should be considered in the investigation of FSHD pathology and therapy. PMID: 29255294
- Transfection experiments showed that the PAX7 splice-site mutation putatively causes nonsense-mediated mRNA decay affecting onlyPAX7 isoform 3. PMID: 28779497
- The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain. PMID: 28935672
- EWSR1 fusion protein is required for PAX7 expression in Ewing sarcoma and identify a candidate EWSR1-FLI1-bound PAX7 enhancer that coincides with both a consensus GGAA repeat-containing binding site and a peak of regulatory H3K27 acetylation. PMID: 28643791
- miR-206 acts as a tumor suppressor in fusion-negative RMS at least partially through downregulation of PAX7. PMID: 27277678
- PAX7 expression is a useful marker of skeletal muscle differentiation in rhabdomyosarcoma, particularly of the embryonal subtype, with specificity for rhabdomyosarcoma and Ewing sarcoma. PMID: 27526298
- NTN1 rs9788972 is identified as a risk locus for nonsyndromic orofacial clefts susceptibility in a northern Chinese population; SNPs in PAX7 were not associated with any increased risk PMID: 28489749
- RAGE upregulates myogenin which upregulates MyoD and downregulates PAX7, with consequent inhibition of proliferation and stimulation of differentiation. PMID: 24554430
- Pax7 responds to NF-kappaB by impairing the regenerative capacity of myogenic cells in the muscle microenvironment to drive muscle wasting in cancer. PMID: 24084740
- High prevalence of 1p36 microdeletions in B-cell non-Hodgkin lymphomas is associated with PAX7 loss. PMID: 23205730
- Our study replicated previous GWAS findings for markers in VAX1 in the Asian population, and identified rare variants in PAX7 and VAX1 that may contribute to the etiology of CL(P) PMID: 23463464
- In addition, eight genes classified as 'second tier' hits in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and association in this replication sample. PMID: 23512105
- SUMOylation of Pax7 is essential for neural crest development in chick embryos and for the inhibitory roles of Pax7 in C2C12-muscle differentiation. PMID: 23247248
- PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation. PMID: 22374423
- Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury and disease. PMID: 21954137
- MyoD can play an active role in Alveolar rhabdomyosarcoma by augmenting Pax7-FKHR function. PMID: 21321994
- PAX7-FKHR gene fusion is prognostic indicator for alveolar rhabdomyosarcoma. PMID: 12039929
- expression of PAX7 is correlated with metastasis potential--REVIEW PMID: 12647804
- elevated PAX7 expression indicates myogenic satellite cell origin for embryonal rhabdomyosarcoma PMID: 12865925
- in the RD embryonal rhabdomyosarcoma cell line, expression of wild-type PAX7 is downregulated by PAX3-FKHR PMID: 15184910
- PAX 7-FKHR fusion transcripts were positive in 2/7 of alveolar rhabdomyosarcoma patients, and were negative in embryonal rhabdomyosarcoma and Control tumors. PMID: 17285543
- Results identified a differentiation-resistant skeletal muscle progenitor cell population that was Pax7+/desmin- and capable of self-renewal. PMID: 19097049
- TAT analysis of all trios revealed two SNPs in PAX7 showing significant excess maternal transmission Isolated cleft lip with or without cleft palate PMID: 19142206
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相關(guān)疾病：Rhabdomyosarcoma 2 (RMS2)
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亞細(xì)胞定位：Nucleus.
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蛋白家族：Paired homeobox family
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