PAX2 Antibody, FITC conjugated
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中文名稱：PAX2兔多克隆抗體, FITC偶聯
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貨號：CSB-PA11564C0Rb
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PAX2 Polyclonal antibody
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Uniprot No.：
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基因名：PAX2
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別名：PAX2 antibody; Paired box protein Pax-2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Paired box protein Pax-2 protein (1-363AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS.
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基因功能參考文獻：
- Our data suggested that high expression of PAX2 could be associated with better survival in estrogen receptor positive tamoxifen-treated breast carcinoma patients. PMID: 29857823
- During the ensuing weeks, the PAX2/FOXA1 boundary progressively extended cranially such that by 21 weeks the entire vaginal epithelium was FOXA1-reactive and PAX2-negative. This observation supports Bulmer's proposal that human vaginal epithelium derives solely from urogenital sinus epithelium PMID: 28918284
- PAX2 is involved in the carcinogenesis of endometrial cancer by stimulating cell growth and promoting cell motility; the overexpression of PAX2 in endometrial cancer is regulated by promoter hypermethylation and the transcription factor MZF1 PMID: 27764784
- This case unravels a previously unrecognized phenotype of camptodactyly due to a significant skeletal deformity of Papillorenal syndrome with a heterogeneous PAX2 mutation of hexanucleotide duplication. PMID: 29054766
- Mutant p53 and PTEN loss negatively regulated PAX2 and PAX2 re-expression in high-grade serous ovarian cancer cells induced cell death. PMID: 27991925
- The polymorphism rs12266644 of PAX2 might be a risk factor for mullerian duct anomalies in Chinese Han females PMID: 27722936
- PAX2, PAX8, CDX2 immunostains was preformed to the TMA slides. PMID: 26797858
- we demonstrated that miR-497 is decreased in human ovarian cancer tissues and cells, and acts as a tumor suppressor. We also confirmed PAX2 is a target gene of miR-497 PMID: 27513319
- Vimentin, Nestin and WT1. Sox2 was expressed by the stem/progenitor cells of the ventricular zone, whereas the postmitotic neurons of the cortical plate were immunostained by PAX2 and NSE. PMID: 26972711
- PAX2 and PAX5 are useful biomarker in the differential diagnosis of lung cancer PMID: 26823795
- a substantial minority of solitary fibrous tumors express nuclear PAX8 and PAX2 PMID: 26404914
- PAX2 gene silencing can significantly inhibit the process of epithelial-mesenchymal transition (EMT) of renal tubular cells in rats with advanced fibrosis. PMID: 27324546
- The results of this study identify several new mutations of PAX2, and sequence variants in four additional genes, including a novel potentially pathogenic mutation in KIF26B, which may play a role in the pathogenesis of Renal Coloboma Syndrome. PMID: 26571382
- data suggested the differential regulation of hDAO expression by two promoters whose activities may be modulated by the binding of PAX2 and PAX5 PMID: 25500505
- Homozygosity for the risk alleles of RET and PAX2 was not seen in the late onset group in primary hyperoxaluria type 1 patients. PMID: 25854853
- PAX2 and PAX8 are useful biomarker in the differential diagnosis of ovarian serous and mucinous tumors PMID: 24992169
- The 798C>T/909A>C PAX2 genotype did not increase the susceptibility to HenochSchonlein purpura (HSP), but it was likely to increase the susceptibility of kidney involvement in HSP patients. PMID: 25385517
- Novel PAX2 targets included multiple genes encoding proteins with predicted functions in the epididymis epithelium. PMID: 25180270
- Results showed that PAX2 expression is significantly overexpressed in esophageal squamous cell carcinoma tissues and IL-5 is identified as PAX2's effector for metastasis. PMID: 25613757
- Report increased Pax2 expression in the ureter epithelium of children with vesicoureteric reflux. PMID: 25912758
- Pax2 may play a role in kidney development by regulating the expression of TBX1. PMID: 25106525
- Immunohistochemical distinction of renal cell carcinoma from other carcinomas with clear-cell histomorphology: utility of CD10 and CA-125 in addition to PAX-2, PAX-8, RCCma, and adipophilin. PMID: 25279712
- PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. PMID: 25631048
- PAX2 was strongly positive in all alveolar rhabdomyosarcomas and in two-thirds of the kidney clear cell sarcomas, and displayed variable expression in one-half of the embryonal rhabdomyosarcomas. PMID: 24897005
- study suggests an association between PAX2 gene polymorphisms and the development of vesicoureteral reflux, but not with ureteropelvic junction obstruction and multicystic dysplastic kidney PMID: 24633556
- study, for the first time, links PAX2-null with proliferating fetal and adult oviductal cells undergoing basal and ciliated differentiation and shows that this expression state is maintained in high-grade serous cancer precursors PMID: 25130537
- PAX2 promotes cancer cell growth in androgen-independent prostate cancer by regulating androgen receptor gene expression through an epigenetic mechanism. PMID: 25132193
- Exome sequencing in an index family with dominant FSGS revealed a nonconservative, disease-segregating variant in the PAX2 gene. Sequencing in probands of a familial FSGS cohort revealed seven rare and private heterozygous SNPs (4% of individuals). PMID: 24676634
- cotransfection of Pax2 and Math1 strongly stimulates in situ hair cell regeneration in neomycin-damaged cochlear explants. PMID: 24141260
- Pax-2 expression might be used as an ancillary tool to discriminate chromophobe renal cell tumour from oncocytomas with overlapping morphological features. PMID: 23890189
- Case Report: sporadic renal hemangioblastoma expressing PAX2. PMID: 24040464
- other genes and/or locus control regions regulating PAX2 may be involved in the pathogenesis of PAX2 mutation-negative cases of RCS. PMID: 23756089
- PAX2 and PAX8 are valuable diagnostic markers for metastatic mullerian carcinomas and renal cell carcinoma in effusion cytology PMID: 24334997
- PAX2 and napsin A have high specificity but low sensitivity and only have limited value in the differential diagnosis of mesotheliomas and renal cell carcinomas PMID: 23503645
- Report high rate of mutations in PAX2 genes known to be involved in monogenic syndromic Congenital anomalies of the kidney and urinary tract. PMID: 23539225
- miR-1915 and miR-1225-5p regulated the expression of important markers of renal progenitors, such as CD133 and PAX2, and important genes involved in the repair mechanisms of adult renal progenitor cells, such as TLR2. PMID: 23861881
- These data suggest that in difficult diagnostic cases both PAX2 and mesothelin immunohistochemical study may be useful in discriminating between PMRCC and primary pancreatic carcinoma. PMID: 24344503
- Immunostains for PAX2 and PAX8 are useful in the detection of nephrogenic adenomas and particularly unveil those nephrogenic adenomas with flat pattern. PMID: 23328975
- PAX2 has little practical value in the diagnosis of peritoneal epithelioid mesotheliomas PMID: 23196794
- Our data suggested that PAX2 hyper-expression promotes the development of the metastatic state in prostate cancer cells, presumably through upregulating the expression of cell membrane proteins. PMID: 23765687
- Cryptorchidism-associated papillorenal syndrome/PAX2 mutation has not been reported. PMID: 23686327
- PAX2 is effective in discriminating cervical adenocarcinoma in situ from benign endocervical glandular epithelium PMID: 23202787
- PAX2 gene is pivotal in kidney development and it is implicated in the pathogenesis of renal interstitial fibrosis (RIF) and glomerulosclerosis (GS). PMID: 23137159
- PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferation of colon cancer cells. PMID: 23135283
- cross-talk between p53 and Pax2 provides a transcriptional platform that promotes nephrogenesis, thus contributing to nephron endowment PMID: 22984579
- investigation of expression of PAX2 and PAX8 in renal biopsy samples as diagnostic markers in the differential diagnosis of various types of primary and secondary renal cell carcinomas PMID: 23194047
- PAX-2, PAX-8, and hKIM-1 should be used cautiously in distinguishing renal cell carcinoma from nonseminomatous germ cell neoplasia and also adds to the growing list of nonrenal tumors that express these 3 markers. PMID: 22495365
- In both monozygotic twins with renal coloboma syndrome, a novel de novo mutation of PAX2 was detected, which leads to the substitution of a highly conserved cysteine (p.C52Y). PMID: 22660956
- Mutations in PAX2 may not be ac ommon cause of Mullerian Duct Abnormalities. PMID: 22683154
- These findings suggest that PAX2 may play a role in endometrial carcinogenesis. PMID: 22274645
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相關疾?。?/div>Papillorenal syndrome (PAPRS); Focal segmental glomerulosclerosis 7 (FSGS7)亞細胞定位：Nucleus.組織特異性：Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.數據庫鏈接：
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