PAPSS2 Antibody
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中文名稱：PAPSS2兔多克隆抗體
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貨號：CSB-PA527262LA01HU
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規格：￥440
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圖片：
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Immunofluorescence staining of MCF-7 cells with CSB-PA527262LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PAPSS2 Polyclonal antibody
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Uniprot No.：
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基因名：PAPSS2
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別名：PAPSS2 antibody; ATPSK2Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 antibody; PAPS synthase 2 antibody; PAPSS 2 antibody; Sulfurylase kinase 2 antibody; SK 2 antibody; SK2) [Includes: Sulfate adenylyltransferase antibody; EC 2.7.7.4 antibody; ATP-sulfurylase antibody; Sulfate adenylate transferase antibody; SAT); Adenylyl-sulfate kinase antibody; EC 2.7.1.25 antibody; 3'-phosphoadenosine-5'-phosphosulfate synthase antibody; APS kinase antibody; Adenosine-5'-phosphosulfate 3'-phosphotransferase antibody; Adenylylsulfate 3'-phosphotransferase)] antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Bifunctional 3\'-phosphoadenosine 5\'-phosphosulfate synthase 2 protein (2-138AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，PAPSS2 Antibody (CSB-PA527262LA01HU)，的標記方式是Non-conjugated。對于PAPSS2 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IF
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推薦稀釋比：
Application Recommended Dilution IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases. In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway. Plays indirectly an important role in skeletogenesis during postnatal growth.
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基因功能參考文獻：
- In an Amish population, using expression profiling of genes within regions identified by a meta-analysis GWAS of survival to age 90, we localized PAPSS2 as a candidate gene for extended life span. These results provide novel evidence for genetic loci implicated in longevity and incorporate gene expression results from a unique population to locate positional candidates. PMID: 26896383
- Silencing of SULT1A1 and PAPSS2 led to a significant decrease in aristolactam-DNA levels in both cell lines following exposure to AA-I, indicating the critical role for sulfonation in the activation of AA-I in vivo Since HK-2 cells proved relatively resistant to knockdown with siRNAs PMID: 27207664
- Our results indicate that FGFR2 and PAPSS2 may play an important role in the regulation of magnesium homeostasis in children of European-American ancestry. PMID: 26685716
- Results suggest that the loss of the susceptible region on chromosome 10q, which implicates PTEN, FAS and PAPSS2 may serve as genetic predictors of PSA recurrence after radical prostatectomy. PMID: 25679447
- Direct in vivo evidence for the significant functional impact of mutant PAPSS2 on DHEA sulfation and androgen activation. PMID: 25594860
- PAPSS2-brachyolmia includes phenotypes of the conventional clinical concept of brachyolmia, the Hobaek and Toledo types, and is associated with abnormal androgen metabolism. PMID: 23824674
- Papss2 expression is reduced in articular cartilage following transforming growth factor-beta administration. PMID: 22394585
- PAPSS2 is the disease gene for an autosomal recessive brachyolmia. PMID: 22791835
- Unusual localisation signals of both PAPS synthase isoforms, are described. PMID: 22242175
- Thirty-seven novel SNPs in the PAPSS2 gene and in two intergenic regions on chromosomes 2q33.1 and 18p11.32 were associated with exercise participation. PMID: 19727025
- Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2. PMID: 11931653
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相關疾病：Brachyolmia type 4 with mild epiphyseal and metaphyseal changes (BCYM4)
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蛋白家族：APS kinase family; Sulfate adenylyltransferase family
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組織特異性：Expressed in cartilage and adrenal gland.
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數據庫鏈接：
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