PAK1IP1 Antibody

說明書

產品詳情

Uniprot No.：

Q9NWT1
基因名：

PAK1IP1
別名：

PAK1IP1 antibody; PIP1 antibody; WDR84 antibody; p21-activated protein kinase-interacting protein 1 antibody; PAK/PLC-interacting protein 1 antibody; hPIP1 antibody; PAK1-interacting protein 1 antibody; WD repeat-containing protein 84 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human PAK1IP1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
基因功能參考文獻：
1. A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. PMID: 23935987
亞細胞定位：

Nucleus, nucleolus.
組織特異性：

Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.
數據庫鏈接：

HGNC: 20882

OMIM: 607811

KEGG: hsa:55003

STRING: 9606.ENSP00000368887

UniGene: Hs.310231

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