P2RX2 Antibody

說明書

中文名稱：

P2RX2兔多克隆抗體
貨號：

CSB-PA244468
規格：

￥1100
圖片：
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA244468(P2RX2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9UBL9
基因名：

P2RX2
別名：

ATP receptor antibody; MGC129601 antibody; P2RX 2 antibody; P2RX2 antibody; P2RX2_HUMAN antibody; P2X purinoceptor 2 antibody; P2X Receptor subunit 2 antibody; P2X2 antibody; P2X2a antibody; Purinergic receptor antibody; Purinergic receptor P2X ligand gated ion channel 2 antibody; Purinergic receptor P2X2 isoform A antibody; Purinergic receptor P2X2 isoform B antibody; Purinergic receptor P2X2 isoform C antibody; Purinergic receptor P2X2 isoform D antibody; Purinergic receptor P2X2 isoform H antibody; Purinergic receptor P2X2 isoform I antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human P2RX2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.
基因功能參考文獻：
1. identified P2RX2, KCNQ5, ERBB3 and SOCS3 to be associated with the progression of age-related hearing impairment PMID: 29325454
2. These findings indicate that the CaMKII-mediated GluA1 phosphorylation of S567 and S831 is critical for P2X2-mediated AMPAR internalization and ATP-driven synaptic depression. PMID: 27624155
3. Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor hP2X2/3 channel. PMID: 27129281
4. Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 and P2X3 subunits PMID: 26184350
5. The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2, P2X3 and P2X7 receptors in the different histological layers of the human urinary bladder. PMID: 26253104
6. A novel mutation in the P2RX2 gene was identified in a MELAS family. PMID: 25788561
7. The locus designated DFNA41 maps to a 15 cM region on chromosome 12q24.32-qter, proximal to the marker D12S1609. PMID: 12161595
8. Molecular analyses of P2RX2 identified a novel missense mutation. PMID: 24211385
9. Data indicate that the P2X2(I328C) receptor was activated by propyl-methanethiosulfonate (MTS) as effectively as by ATP. PMID: 24273165
10. Data indicate that MgATP2- activates P2X1 and P2X3, but not P2X2 and P2X4 receptors. PMID: 23959888
11. the contribution of the extracellular, transmembrane, and intracellular segments to recovery from desensitization PMID: 23740251
12. analysis of dominantly inherited, progressive sensorineural hearing loss DFNA41 in a six-generation kindred revealed a rare heterozygous allele, P2RX2 c.178G > T (p.V60L), at chr12:133,196,029, which cosegregated with fully penetrant hearing loss PMID: 23345450
13. trimeric P2X receptors containing only two intact binding sites can be readily activated by ATP. PMID: 22828800
14. High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism PMID: 22556417
15. one subunit of P2X2 and two subunits of P2X3 form P2X2/3 heteromeric receptors, whereas two subunits of P2X2 and one subunit of P2X6 constitute P2X2/6 receptors PMID: 22378790
16. Studies indicate that P2X1, P2X2, and P2X4 receptors are detected in preglomerular microvessels. PMID: 21768526
17. analysis of agonists trapped in ATP-binding sites of the P2X2 receptor PMID: 21576497
18. GABA(A) receptor dynamics are regulated by interaction with purinergic P2X(2) receptors PMID: 21343285
19. Data suggest that interactions between alpha3beta4 nAChRs and P2X2 receptors may modulate transmission at enteric synapses that use ATP and acetylcholine as co-transmitters. PMID: 20426799
20. Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP PMID: 20699225
21. Whole-cell voltage clamp recordings functionally correlated immunolocalisation of ATP-gated ion channels in isolated hair cells and supporting cells. P2X immunoreactivity was widespread throughout the epithelial lining of the cochlea. PMID: 12395104
22. Data provide biochemical evidence that in addition to the rapidly desensitising P2X1 and P2X3 receptors, the slowly desensitising subtypes P2X2, P2X4, and P2X5 are trimers of identical subunits. PMID: 15313628
23. Effect of acute hypoxia on cloned homo- and heteromeric P2X2 receptors expressed in human embryonic kidney 293 cells. PMID: 15331767
24. P2X(2) receptors are trimers, whereas the P2X(6) receptor subunits do not form stable oligomers PMID: 15657042
25. support a common site of ATP action at P2X receptors and suggest that non-conserved residues also play a regulatory role in agonist action PMID: 18487206
26. VILIP1 constitutively binds to P2X2 receptors and displays enhanced interactions in an activation- and calcium-dependent manner owing to exposure of its binding segment in P2X2 receptors PMID: 18922787
27. Specimens (12/15) from patients with spinal cord lesions and specimens (8/11) demonstrated strong staining for P(2)X(2) receptors in the detrusor muscle and the urothelium. PMID: 19104511
28. Intracellular cysteine430 residue mediates the potentiation of P2X2 receptor activity by reactive oxygen species. PMID: 19793987
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相關疾病：

Deafness, autosomal dominant, 41 (DFNA41)
亞細胞定位：

Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membranes of hair cells in the organ of Corti.
蛋白家族：

P2X receptor family
數據庫鏈接：

HGNC: 15459

OMIM: 600844

KEGG: hsa:22953

UniGene: Hs.258580

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