OXSR1 Antibody
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中文名稱：OXSR1兔多克隆抗體
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貨號：CSB-PA080106
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：OXSR1
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別名：2210022N24Rik antibody; 2810422B09Rik antibody; AI462649 antibody; AW209236 antibody; KIAA1101 antibody; mKIAA1101 antibody; OSR 1 antibody; OSR1 antibody; OTTHUMP00000209062 antibody; Oxidative stress responsive 1 antibody; Oxidative stress responsive 1 protein antibody; Oxidative stress-responsive 1 protein antibody; OXSR 1 antibody; OXSR1 antibody; OXSR1_HUMAN antibody; Serine/threonine protein kinase OSR1 antibody; Serine/threonine-protein kinase OSR1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the Internal region of Human OXSR1.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Phosphorylates RELL1, RELL2 and RELT. Phosphorylates PAK1. Phosphorylates PLSCR1 in the presence of RELT.
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基因功能參考文獻：
- Data demonstrate that hypotonic low-chloride conditions that activate the WNK1-SPAK and OSR1 pathway promote phosphorylation of NKCC2 isoforms. PMID: 21321328
- OSR1 and SPAK integrate signals from osmosensing and survival pathways. PMID: 24191005
- our data show a novel role for the WNK1/OSR1/NKCC1 pathway in glioma migration PMID: 24555568
- SPAK and OSR1 are powerful negative regulators of the cell volume regulatory Cl- channel ClC-2 PMID: 25323061
- study identifies a separation of functions for the WNK1-activated protein kinases OSR1 and SPAK in mediating proliferation, invasion, and gene expression in endothelial cells PMID: 25362046
- The CCT domain directly interacts with the kinase domain to block substrate access and inhibit the domain-swapped homodimerization of the kinase domain of OSR1. PMID: 25389294
- WNK 1, 3, 4, OSR1, and SPAK signaling system known to play a role in regulating the phosphorylation status, and hence activity of the CCCs in other tissues, is also present in the rat and human lenses. PMID: 25515571
- OSR1 has the capacity to downregulate the peptide transporters PEPT1 and PEPT2 by decreasing the carrier protein abundance in the cell membrane PMID: 25531100
- Both, SPAK and OSR1, are negative regulators of the creatine transporter SLC6A8 PMID: 25531585
- SPAK and OSR1 are negative regulators of EAAT3 activity PMID: 26112741
- SPAK and OSR1 are powerful negative regulators of the excitatory glutamate transporters EAAT1 and EAAT2. PMID: 26233565
- SPAK and OSR1 are powerful stimulators of the intestinal Na+-coupled phosphate co-transporter NaPi-IIb PMID: 26506223
- OSR1 protein has both the potential to up-regulate KCNQ1/E1 protein abundance in the cell membrane, an effect possibly participating in the regulation of cell volume, excitability, epithelial transport and metabolism. PMID: 26584301
- SPAK and OSR1 are both stimulators of Kir2.1 activity. PMID: 26673921
- Both SPAK and OSR1 kinases entering cells through exosomes are preferentially expressed at the plasma membrane and that the kinases in exosomes are functional and maintain NKCC1 in a phosphorylated state. PMID: 27122160
- the WNK-regulated SPAK/OSR1 kinases directly phosphorylate the N[K]CCs and KCCs, promoting their stimulation and inhibition respectively. PMID: 24393035
- SPAK and OSR1, which are often coexpressed in cells, can form functional heterodimers. PMID: 23034389
- Data show that intracellular association between WNK1 and oxidative stress-responsive 1 (OSR1) is required for stimulation of OSR1 and Na(+), K(+), Cl(-)-Cotransporter NKCC1 and NKCC2 activities by osmotic stress. PMID: 22989884
- OXSR1 and WNK3 transcripts were substantially overexpressed in subjects with schizophrenia relative to comparison subjects. PMID: 20819979
- interacts with cation chloride cotransporters PMID: 12386165
- isolation and characterization of OSR1 (oxidative stress-responsive 1), one of two human Fray homologs. OSR1 is a 58-kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines PMID: 14707132
- WNK1 and SPAK/OSR1 mediate the hypotonic stress signaling pathway to cation-chloride-coupled cotransporters PMID: 16263722
- OXSR1 kinase is shown to interact with the three RELT family members RELT, RELL1, and RELL2 by in vitro co-immunoprecipitation; additionally, OXSR1 phosphorylates RELT family members in an in vitro kinase assay. PMID: 16389068
- data establish that the CCT domain functions as a multipurpose docking site, enabling SPAK/OSR1 to interact with substrates (NKCC1) and activators (WNK1/WNK4) PMID: 16669787
- OSR1 and sterile20-related, proline-, alanine-rich kinase are likely links between WNK lysine deficient protein kinase 1 and solute carrier family 12 in a pathway that contributes to volume regulation and blood pressure homeostasis in mammals PMID: 16832045
- These results provide the first molecular insight into the mechanism by which the SPAK and OSR1 kinases specifically recognize their upstream activators and downstream substrates. PMID: 17721439
- The WNK1-SPAK/OSR1 signalling pathway plays a key role in controlling the phosphorylation and activity of NCC. PMID: 18270262
- The first crystal structure of an OSR1 fragment encompassing the catalytic domain of the enzyme, is reported. PMID: 18831043
- crystal structure of OSR1 kinase domain has been solved at 2.25 A; OSR1 forms a domain-swapped dimer in an inactive conformation, in which P+1 loop and alphaEF helix are swapped between dimer-related monomers PMID: 19177573
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亞細胞定位：Cytoplasm.
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蛋白家族：Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
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組織特異性：Ubiquitously expressed in all tissue examined.
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數據庫鏈接：
