OTUD5 Antibody, FITC conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) OTUD5 Polyclonal antibody
Uniprot No.：

Q96G74
基因名：

OTUD5
別名：

Deubiquinating enzyme A antibody; Deubiquitinating enzyme A antibody; DKFZp761A052 antibody; DUBA antibody; MGC104871 antibody; OTTHUMP00000025821 antibody; OTU domain containing 5 antibody; OTU domain containing protein 5 antibody; OTU domain-containing protein 5 antibody; OTUD 5 antibody; otud5 antibody; OTUD5_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human OTU domain-containing protein 5 protein (51-183AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro).
基因功能參考文獻：
1. Findings have uncovered an apoptotic signaling cascade linking PDCD5, OTUD5, and p53 during genotoxic stress responses. PMID: 25499082
2. OTUD5 is required for the stabilization and the activation of a p53 response PMID: 24143256
3. Here the authors show that phosphorylation of the human deubiquitinase DUBA (OTUD5) at a single residue, Ser177, is both necessary and sufficient to activate the enzyme. PMID: 22245969
4. data identify DUBA as a negative regulator of innate immune responses PMID: 17991829
蛋白家族：

Peptidase C85 family
組織特異性：

Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.
數據庫鏈接：

HGNC: 25402

OMIM: 300713

KEGG: hsa:55593

STRING: 9606.ENSP00000156084

UniGene: Hs.496098

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