OSBPL2 Antibody
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中文名稱：OSBPL2兔多克隆抗體
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貨號：CSB-PA017248GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：OSBPL2
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別名：FLJ20223 antibody; KIAA0772 antibody; MGC4307 antibody; MGC8342 antibody; ORP-2 antibody; ORP2 antibody; OSBL2_HUMAN antibody; OSBP related protein 2 antibody; OSBP-related protein 2 antibody; OSBPL2 antibody; Oxysterol binding protein like 2 antibody; Oxysterol binding protein related protein 2 antibody; Oxysterol-binding protein-related protein 2 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human OSBPL2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro).
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基因功能參考文獻：
- point at a novel function of ORP2 as a lipid-sensing regulator of the actin cytoskeleton, with impacts on hepatocellular migration, adhesion, and proliferation PMID: 29092904
- this study identifies ORP2 as a new regulatory nexus of Akt signaling, cellular energy metabolism, actin cytoskeletal function, cell migration, and proliferation. PMID: 29947926
- a novel role for ORP2 in regulating steroidogenic capacity and cholesterol homeostasis in the adrenal cortex PMID: 26992564
- This study and the recent description of another frameshift mutation in a Chinese ADNSHL family identify OSBPL2 as a novel gene for progressive deafness. PMID: 25759012
- Results identified frameshift and missense mutation in OSBPL2 gene in familial and sporadic case of deafness suggesting OSBPL2 as a novel candidate gene for autosomal dominant nonsyndromic hearing loss . PMID: 25077649
- ORP2 as a novel regulator of cellular sterol homeostasis and intracellular membrane trafficking. PMID: 11861666
- Results identify ORP2 as a sterol receptor present on LD and provide evidence for its role in the regulation of neutral lipid metabolism, possibly as a factor that integrates the cellular metabolism of triglycerides with that of cholesterol. PMID: 19224871
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相關疾病：Deafness, autosomal dominant, 67 (DFNA67)
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亞細胞定位：Cytoplasm, cytosol. Lipid droplet. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
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蛋白家族：OSBP family
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組織特異性：Widely expressed.
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數據庫鏈接：
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