ORAOV1 Antibody
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中文名稱：ORAOV1兔多克隆抗體
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貨號：CSB-PA003600
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規格：￥1090
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圖片：
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Western Blot analysis of HeLa cells using ORAOV1 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：ORAOV1
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別名：LTO1 antibody; ORAOV1 antibody; TAOS1Protein LTO1 homolog antibody; Oral cancer-overexpressed protein 1 antibody; Tumor-amplified and overexpressed sequence 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human ORAOV1.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. May play a role in the regulation of proline metabolism and ROS production.
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基因功能參考文獻：
- provides the first evidence of ORAOV1 overexpression in esophageal squamous cell cancer and esophageal squamous intraepithelial neoplasia PMID: 25732110
- the ORAOV1 gene is frequently amplified in esophageal squamous cell cancer PMID: 24930674
- The ORAOV1 complex could prevent ROS-induced ribosomal damage, explaining why overexpression of ORAOV1 is so common in solid tumours PMID: 23318452
- overexpression of ORAOV1 in non-tumoral margin samples can occur in absence of amplification. weak correlation between ORAOV1 amplification and expression in OSSC suggests ORAOV1 expression can be regulated by mechanisms other than gene amplification. PMID: 21623924
- An oral cancer overexpressed 1 (ORAOV1) gene was identified as a probable target within the 11q13 amplicon in lymph node metastases from gastric adenocarcinoma. PMID: 21993861
- ORAOV1 has an important role in regulating cell growth of cervical cancer HeLa cells through regulating the cell cycle and apoptosis. PMID: 20105337
- High-resolution mapping of the 11q13 amplicon and identification of a gene that is amplified and overexpressed in oral cancer cells PMID: 12172009
- data suggested potential roles in oral carcinogenesis and that TAOS1 might be involved earlier than EMS1. Both genes might be candidate biomarkers for diagnosis and prognosis in OSCC PMID: 17005439
- ORAOV1 plays pivotal roles in the growth and angiogenesis of oral squamous cell carcinoma. PMID: 18688849
- In OSCC tissue samples, the expression frequency of ORAOV1-A (51.1%) was much higher than that in normal samples (10.5%). ORAOV1-A may play a functional role in the tumorigenesis of OSCC. PMID: 19493886
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亞細胞定位：Nucleus.
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蛋白家族：ORAOV1 family
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組織特異性：Widely expressed. Highly expressed in placenta, kidney and skeletal muscle.
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數據庫鏈接：
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