OPCML Antibody
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中文名稱：OPCML兔多克隆抗體
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貨號：CSB-PA055401
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規格：￥1100
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圖片：
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Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA055401(OPCML Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：GM181 antibody; IgLON family member 1 antibody; IGLON1 antibody; OBCAM antibody; OPCM antibody; OPCM_HUMAN antibody; OPCML antibody; Opiate binding cell adhesion molecule antibody; Opioid binding cell adhesion molecule antibody; Opioid binding protein/cell adhesion molecule antibody; Opioid binding protein/cell adhesion molecule-like antibody; Opioid binding protein/cell adhesion molecule-like preprotein antibody; Opioid-binding cell adhesion molecule antibody; Opioid-binding protein/cell adhesion molecule antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human OPCML
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds opioids in the presence of acidic lipids; probably involved in cell contact.
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基因功能參考文獻：
- Here we show that, though OPCML interacts only with HER2 and not with EGFR, the interaction of OPCML with HER2 disrupts the formation of the HER2-EGFR heterodimer, and this translates into a better response to both lapatinib and erlotinib in HER2-expressing ovarian and breast cancer cell lines PMID: 28775148
- Study revealed that reduced expression of OPCML might have a significant correlation with unfavorable tumor stage and differentiation, predict poor prognosis of patients with gastric cancer. OPCML had a tumor-suppressing activity possibly via AKT/GSK3beta signaling in gastric cancer. PMID: 28407749
- OPCML and FLRT2 were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci PMID: 26890304
- OPCML plays an important role in gastric cancer, and may be a new prognostic indicator of gastric cancer. PMID: 27358143
- the DNA methylation levels of OPCML and SFRP1 could be potential biomarkers for diagnosis of CCA with high specificity, sensitivity, and accuracy, in particular for biopsy specimens PMID: 25652468
- The generation and cardiac phenotype of single and double heterozygous gene-targeted OPCML and Neurotrimin knockout mice. PMID: 24616287
- Detection of OPCML hypermethylation in the serum is useful for diagnosis of ovarian carcinoma. PMID: 24839818
- The OPCML tumor suppressor negatively regulates a specific spectrum of receptor tyrosine kinases in ovarian cancer cells by binding to their extracellular domain. PMID: 22585860
- A strong association was found between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population PMID: 21833655
- opioid binding protein/cell adhesion molecule-like promoter methylation has a role in bladder carcinoma PMID: 21273058
- OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer PMID: 12819783
- Oncogenic RAS activity is directly responsible for the observed OPCML promoter hypermethylation and epigenetic gene silencing of OPCML. PMID: 16384911
- The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer. PMID: 17109515
- Hypermethylation of OPCML gene is responsible for silencing and loss of suppressor function in ovarian cancer. PMID: 17159813
- OPCML down-regulation occurs in the majority of brain tumours tested PMID: 17239010
- Results identified OPCML loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma. PMID: 17967182
- loss of OPCML expression occurs frequently in ovarian serous carcinoma. CpG island methylation and LOH are probably two mechanisms of OPCML inactivation PMID: 18179137
- OPCML gene promoter methylation may play an important role in the carcinogenesis of cervical carcinoma. OPCML may be a cervical carcinoma-associated candidate tumor suppressor gene. PMID: 18584347
- OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies. PMID: 18714356
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相關疾病：Ovarian cancer (OC)
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亞細胞定位：Cell membrane; Lipid-anchor, GPI-anchor.
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蛋白家族：Immunoglobulin superfamily, IgLON family
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數據庫鏈接：
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