OLFM4 Antibody, Biotin conjugated
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中文名稱：OLFM4兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA764941LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) OLFM4 Polyclonal antibody
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Uniprot No.：
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基因名：OLFM4
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別名：Antiapoptotic protein GW112 antibody; bA209J19.1 antibody; G-CSF-stimulated clone 1 protein antibody; GC1 antibody; GW112 antibody; hGC 1 antibody; hGC-1 antibody; hOLfD antibody; KIAA4294 antibody; olfactomedin 4 antibody; Olfactomedin-4 antibody; OlfD antibody; OLFM4 antibody; OLFM4_HUMAN antibody; OLM4 antibody; UNQ362 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Olfactomedin-4 protein (224-334AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
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基因功能參考文獻：
- Study results suggest that OLFM4, LY6D and S100A7 immunoreactivity are associated with an aggressive phenotype of estrogen receptor (ER)-positive breast carcinoma, and these are potent markers for distant metastasis of ER-positive breast cancer patients. PMID: 30137688
- these data propose that hCG is not a key regulator of cellular alterations within peripheral blood dendritic cells PMID: 29488661
- discovered that OLFM4, CD11b, and ITGA2 are proteins that are overexpressed in both primary colon tumors and liver metastasis. These are colon cancer biomarkers with autoantigenic properties. PMID: 28669815
- MiR-103 acts as an oncogene miRNA to promote triple-negative breast cancer cells migration and invasion through targeting OLFM4. PMID: 28320108
- OLFM4 has an important role in the regulation of intestinal inflammation and tumorigenesis, and could be a potential therapeutic target for intestinal malignant tumors. Unlike the human colonic epithelium, the mouse colonic epithelium does not express OLFM4, but nevertheless, systemic OLFM4 deletion promotes colon tumorigenesis and that loss from mucosal neutrophils may have a role to play. PMID: 26973250
- Olfactomedin-4 identifies a subpopulation of neutrophils in patients with septic shock, and those with a high percentage of olfactomedin-4+ neutrophils are at higher risk for greater organ failure burden and death. Olfactomedin-4 might serve as a marker of a pathogenic neutrophil subset in patients with septic shock PMID: 27635771
- OLFM4 is proved to as a functional target for miR-590. PMID: 28012926
- Olfactomedin 4 is a novel tumor marker for triple-negative breast cancer for predicting and prognosis. PMID: 27939521
- OLFM4 is downregulated by miR-486-5p, which contributes to ovarian cancer tumorigenesis. Conversely, estrogen receptor signaling downregulates miR-486-5p and upregulates OLFM4 expression, slowing the development and progression of ovarian cancer. PMID: 26871282
- Data show that olfactomedin 4 (OLFM4) is highly expressed in proliferating benign epithelial cells and in some carcinoma cells. PMID: 26416558
- olfactomedin 4 appears to play a critical role in regulating progression of prostate cancer, and has potential as a new biomarker for prostate cancer. PMID: 26581960
- Study demonstrates that epigenetic silencing of OLFM4 enhances gastric cancer cell invasion via activation of FAK signaling. PMID: 26303970
- suppression of OLFM4 expression may be a promising strategy in the development of novel cancer therapeutic drugs PMID: 26398045
- Patients with an OLFM4 gene expression level above -7.5 were 6 times more likely to develop severe disease, after correction for age at hospitalization and gestational age. PMID: 26162090
- Using a human vaginal epithelial cell line, the expression of mucin 5 subtype B and olfactomedin-4 were down-regulated in response to N9, suggesting these markers could apply to humans PMID: 25333937
- findings suggest that OLFM4 is not only involved in early stages of gastric carcinogenesis but also a useful prognostic marker for advanced gastric cancer PMID: 26070873
- OLM4 expression is increased in the early stages of gastric, colorectal, and pancreatic cancer initiation. PMID: 25400027
- High expression of GW112 in colorectal cancer tissues and reduced expression of GRIM-19 in colorectal cancer tissues may be associated with abnormal proliferation of cancer cells. PMID: 26011333
- although low OLFM4 expression is not an independent prognostic biomarker, it might indicate worse prognosis for smoking patients with non-small cell lung cancer PMID: 25771901
- Impairment of ERalpha signal-mediated OLFM4 expression promoted the malignant progression of endometrioid adenocarcinoma. PMID: 24495253
- OLFM4 is a novel candidate tumor-suppressor gene for chromosome 13q and may shed new light on strategies that could be used for the diagnosis, prognosis, and treatment of prostate cancer patients. PMID: 24070418
- Reduced expression of olfactomedin 4 and ectopic expression of claudin-18 might be useful markers in the differential diagnosis of serrated polyps. PMID: 23570326
- OLFM4 is overexpressed in active IBD and secreted into mucus. OLFM4 seems to be of functional relevance in IBD as a mucus component, possibly by binding defensins. PMID: 22398066
- OLFM4 regulates host defense against a broad range of bacteria including Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli in an OLFM4-deficient mouse model. PMID: 22844115
- depletion of OLFM4 significantly inhibits tumorigenicity of the gastric cancer SGC-7901 and MKN45 cells. Blocking OLFM4 expression can sensitize gastric cancer cells to H2O2 or TNF alpha treatment by increasing caspase-3 dependent apoptosis. PMID: 22471589
- Single nucleotide polymorphism in OLFM4 gene is associated with childhood obesity. PMID: 22484627
- OLFM4 identifies a subset of human neutrophils. PMID: 22187488
- Our results also indicate that OLFM4 is regulated by the Ras-NF-kappaB2 pathway, one of the main oncogenic pathways deregulated in colorectal tumors PMID: 21986994
- Results suggest that S100B, TM4SF3, and OLFM4 overexpression may affect metastatic behavior of tumor cells in Taiwanese colorectal cancer patients. PMID: 22011044
- The expression of OLFM4 mRNA or protein differed significantly among gastric tumor tissue, matched normal gastric mucosa, and lymph node metastases. PMID: 21904905
- OLFM4 expression and its biological significances in tumor differentiation and progression as well as the contributions of OLFM4 to tumorigenesis (Review) PMID: 21067260
- protection of AGT and resistance to nitrosamine-induced genotoxicity critically depends on GSNOR in hepatocytes PMID: 21470957
- miR-486 antioncogenic activity may involve the direct targeting and inhibition of OLFM4. PMID: 21415212
- Olfactomedin 4 expression has been associated with progression of cervical intraepithelial neoplasia and differentiation of cervical cancer. PMID: 21270618
- Results show that cross-talk between estrogen and EGF signaling regulates OLFM-4 expression in human endometrium. PMID: 21048224
- Review critically evaluates recent advances in understanding of the transcriptional regulation of OLFM4 and its upstream signalling pathways with special emphasis on carcinogenesis and outline future perspectives in the field PMID: 20878207
- OLFM4 plays an important role in myeloid leukemia cellular functions PMID: 20724538
- Data show that granulocyte colony stimulating factor stimulated clone-1, an extracellular matrix glycoprotein, facilitates cell adhesion. PMID: 16566923
- The expression pattern of hGC-1 protein in 173 cases of gastric carcinoma was investigated and a striking correlation was demonstrated between hGC-1 expression and histological type and differentiation of gastric carcinoma. PMID: 17650212
- hGC-1 may be a useful marker for tumor differentiation and progression of human colon carcinoma. PMID: 18281536
- We generated human monoclonal antibodies against 2 potential tumor targets, NGAL and GW112, and we proved their selective expression in cancer colon and not or barely in healthy tissues. PMID: 18798264
- OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. PMID: 19450592
- High serum olfactomedin 4 is associated with gastric cancer. PMID: 19670418
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亞細胞定位：Secreted, extracellular space. Mitochondrion.
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組織特異性：Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone mar
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