NUTF2 Antibody
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中文名稱：NUTF2兔多克隆抗體
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貨號：CSB-PA006428
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規格：￥1090
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圖片：
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Western Blot analysis of HeLa cells using NTF2 Polyclonal Antibody -
Western Blot analysis of Hela cells using NTF2 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：NTF 2 antibody; NTF-2 antibody; NTF2 antibody; NTF2_HUMAN antibody; Nuclear transport factor 2 antibody; Nutf2 antibody; Placental protein 15 antibody; PP15 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human NTF2.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
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基因功能參考文獻：
- These results showed that BLM enters the nucleus via the importin beta1, RanGDP and NTF2 dependent pathway, demonstrating for the first time the nuclear trafficking mechanism of a DNA helicase. PMID: 29017749
- Binding of Ran to NTF2 is required for NTF2 to inhibit nuclear expansion and import of large cargo molecules. PMID: 26823604
- Nucleocytoplasmic translocation of NTF2 is regulated in mammalian cells. PMID: 22880006
- Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation. PMID: 21195711
- A nuclear pore binding site was studied on a mutated NTF2 protein. PMID: 15522285
- Results report that NTF2 and Ran control nuclear import of the filamentous actin capping protein CapG. PMID: 18266911
- NTF2 is a potential mediator of retinal vasculature integrity. PMID: 19404486
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亞細胞定位：Cytoplasm, cytosol. Nucleus outer membrane. Nucleus, nuclear pore complex. Nucleus inner membrane. Nucleus, nucleoplasm.
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數據庫鏈接：
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