NSMCE2 Antibody

中文名稱：

NSMCE2兔多克隆抗體
貨號：

CSB-PA836260LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA836260LA01HU diluted at 1:600 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) NSMCE2 Polyclonal antibody
Uniprot No.：

Q96MF7
基因名：

NSMCE2
別名：

C8orf36 antibody; E3 SUMO-protein ligase NSE2 antibody; hMMS21 antibody; hNSE2 antibody; methyl methanesulfonate sensitivity gene 21 antibody; MMS21 antibody; MMS21 homolog antibody; non-SMC element 2 antibody; Non-SMC element 2 homolog antibody; Non-structural maintenance of chromosomes element 2 homolog antibody; NSE2 antibody; NSE2_HUMAN antibody; Nsmce2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human E3 SUMO-protein ligase NSE2 protein (1-247AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，NSMCE2 Antibody (CSB-PA836260LA01HU)，的標(biāo)記方式是Non-conjugated。對于NSMCE2 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA836260LB01HU	NSMCE2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836260LC01HU	NSMCE2 Antibody, FITC conjugated
Biotin	CSB-PA836260LD01HU	NSMCE2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
基因功能參考文獻(xiàn)：
1. Absence of NSMCE2 affects survival upon topoisomerase II inhibitor etoposide-induced DNA double-strand breaks double-strand breaks. PMID: 27792189
2. our study identified novel PVT1-NSMCE2 and CCDC26-NSMCE2 fusion genes that may play functional roles in leukemia. PMID: 25245984
3. support a role for NSMCE2 in recovery from DNA damage and raise the possibility that loss of its function produces dwarfism through reduced tolerance of replicative stress PMID: 25105364
4. show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1 PMID: 22751501
5. Studies indicate that Nse1 may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex. PMID: 21550342
6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20460480
8. the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells PMID: 16055714
9. MMS21 dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression and that this function appears to be independent of SMC6. PMID: 19502785
10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19549807
11. Observational study of gene-disease association. (HuGE Navigator) PMID: 18163389
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相關(guān)疾?。?/div>
Seckel syndrome 10 (SCKL10)
亞細(xì)胞定位：

Nucleus. Chromosome, telomere. Nucleus, PML body.
蛋白家族：

NSE2 family
數(shù)據(jù)庫鏈接：

HGNC: 26513

OMIM: 617246

KEGG: hsa:286053

STRING: 9606.ENSP00000287437

UniGene: Hs.388297

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