NRXN3 Antibody
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中文名稱：NRXN3兔多克隆抗體
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貨號：CSB-PA070298
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：NRXN3
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別名：NRXN3 antibody; KIAA0743 antibody; Neurexin-3-beta antibody; Neurexin III-beta) [Cleaved into: Neurexin-3-beta antibody; soluble form; Neurexin-3-beta antibody; C-terminal fragment antibody; NRXN3-CTF)] antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the N-terminal region of Human Neurexin IIIβ.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis.
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基因功能參考文獻：
- NRXN2 may play a part in early cortical synaptogenesis, but NRXNs could have diverse roles in development including axon guidance, and intercellular communication between proliferating cells and/or migrating neurons. PMID: 28013231
- The rare variants in NRXN3 were significantly associated with smoking status. PMID: 25450229
- This study confirmed the genetic heterogeneity of cluster headache, suggesting that a novel rearrangement involving NRXN3 gene might be related to cluster headache in a subset of cases PMID: 24469609
- The study showed that markers rs2217887 (NRXN3) showed weak associations. PMID: 24444492
- a positive association between Neurexin 3 and controls in the Han Chinese population, and genetic evidence to support the susceptibility of DEACMP PMID: 24265751
- Neurexin 3-alpha (NRXN3) is a synaptic cell-cell adhesion molecule involved in maintenance of neural connections (such as the maintenance of smoking behavior). PMID: 23909413
- By age 7, common variations in FTO, TMEM18 and NRXN3 influence the vulnerability to metabolic complications of sleep deprivation. PMID: 22391885
- Our findings suggested that NRXN3 might represent a major susceptibility gene for schizophrenia PMID: 23306218
- the study finds preliminary evidence for the association of NRXN3 with Borderline Personality Disorder phenotypes. The strongest association with positive screening for BPD was found for SNP rs10083466. PMID: 23245376
- FoxQ1 promotes glioma cell proliferation and migration by down-regulation of NRXN3 expression. PMID: 23383267
- NRXN3 polymorphisms play a role in susceptibility to smoking behavior and are strongly implicated in human genetic vulnerability to addictive behaviors. PMID: 22716474
- Association of the Graves disease phenotype with two markers, rs12147587 and rs2284720, located within the NRXN3 and TSHR genes, respectively. PMID: 23118423
- N-terminal sequencing of rat neurexin III alpha provides evidence for signal peptide PMID: 9856994
- N-terminal sequencing of cow neurexin III beta provides evidence for signal peptide PMID: 8163501
- alpha- and gamma-secretases can sequentially process NRXN3beta, leading to the formation of two final products, an approximately 80-kDa N-terminal extracellular domain of Neurexin-3beta (sNRXN3beta) and an approximately 12-kDa C-terminal intracellular NRXN3beta domain (NRXN3beta-ICD) PMID: 21084300
- Six NRXN3 polymorphisms were genotyped: rs983795, rs11624704, rs917906, rs1004212, rs10146997 and rs8019381 associated with impulsivity and substance abuse. PMID: 21676558
- NRXN3 single nucleotide polymorphism rs10146997 was significantly (P = 0.0445) associated with higher risk of breast cancer development (OR = 0.66 (95% CI 0.44-0.99)). PMID: 21688152
- Index cases of autism spectrum were clinically characterized who have rare microdeletions at 14q24.3-31.1, a region that overlaps exons of the alpha and/or beta isoforms of NRXN3. PMID: 22209245
- Our results reveal that menopause influences the adipose tissue expression of many genes, especially of neurexin 3, metallothionein 1E, and keratyn 7, which are associated with the alteration of several key biological processes. PMID: 21358552
- central obesity-associated variants in LYPLAL1, NRXN3, MSRA, and TFAP2B PMID: 21674055
- Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia. PMID: 19658047
- Identification and characterization of heart-specific splicing of neurexin 3 mRNA PMID: 12379233
- details of NRXN3's gene structure and variants, and association of NRXN3 SNPs with alcohol dependence PMID: 17804423
- Variants in NRXN3 are associated with waist circumference, body mass index and obesity. PMID: 19557197
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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蛋白家族：Neurexin family
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組織特異性：Expressed in the blood vessel walls (at protein level).
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數據庫鏈接：
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