NRGN Antibody
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中文名稱：NRGN兔多克隆抗體
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貨號：CSB-PA016081GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：NRGN
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別名：Protein kinase C substrate RC3 antibody; Calmodulin binding protein antibody; Hng antibody; NEUG(55-78) antibody; NEUG_HUMAN antibody; Neurogranin (protein kinase C substrate) antibody; Ng antibody; NRGN antibody; Protein kinase C substrate antibody; RC3 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human NRGN
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium.
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基因功能參考文獻：
- The dynamics of calmodulin interactions with neurogranin and Ca(2+) /CAMKII alpha proteins has been reported. PMID: 28449373
- Plasma neurogranin did not correlate with stroke severity. PMID: 28854881
- Study observed an association of rs12807809 with schizophrenia in a South Indian population. This study contributes toward the establishment of neurogranin as a susceptibility gene for schizophrenia South Indian Population. PMID: 28389239
- associations of neuromodulin and neurogranin to Alzheimer's disease PMID: 27604409
- The results of this results showed that increased CSF neurogranin levels in Alzheimer Disease. PMID: 27018940
- Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population. PMID: 26828755
- Neurogranin and YKL-40 are promising AD biomarkers, independent of and complementary to the established core Alzheimer's disease (AD) biomarkers, reflecting additional pathological changes in the course of AD PMID: 26698298
- These results confirm an increase in CSF Ng concentration in patients with AD as previously reported and show that this is specific to AD and not seen in a range of other neurodegenerative diseases. PMID: 26826204
- This report provides evidence to support larger and controlled traumatic brain injury clinical studies for NRGN validation and prediction of outcomes. PMID: 26025774
- Within-person levels of NGRN increased in cognitively normal participants but not in patients with later stage mild cognitive impairment or Alzhiemer's disease; NGRN may reflect presymptomatic synaptic dysfunction or loss. PMID: 26366630
- Cerebrospinal fluid neurogranin was increased in patients with Alzheimer's dementia, progressive mild cognitive impairment (MCI) and stable MCI compared with controls, and in Alzheimer's dementia and progressive MCI compared with stable MCI. PMID: 26373605
- neurogranin binds to alpha-synuclein in the human cortex, and this interaction decreases in Parkinson's disease along with the phosphorylation of neurogranin, a molecular process thought to be involved in learning and memory PMID: 25446004
- These findings help to clarify underlying NRGN mediated pathophysiological mechanisms involving cortical-subcortical brain networks in schizophrenia. PMID: 24386483
- Data indicate that neurogranin makes contacts with both the N- and C-domains of calmodulin that functionally leads to altered calcium binding kinetics. PMID: 24713697
- NRGN risk variants contribute to subtle changes in neural functioning and anatomy. PMID: 24098564
- Our results support an association between the NRGN gene and schizophrenia and a hypothesis that the NRGN gene may mediate the risk associated with schizophrenia via intellectual dysfunction. PMID: 23903071
- The influence of NRGN genotype on the neural correlates of memory encoding and retrieval is manifest in the cingulate cortex and is involved in hippocampal formation. PMID: 21799211
- single nucleotide polymorphism located upstream of the neurogranin (NRGN) gene has been identified as a risk variant for schizophrenia. PMID: 22856365
- This study demonistrated that multiple rare mutations in schizophrenia, and provides genetic clues that indicate the involvement of NRGN in this disorder. PMID: 22306195
- This study provides further evidence of the association of the NRGN gene with schizophrenia. PMID: 22461181
- The genome-wide associated genetic risk variant in the NRGN gene may be related to a small gray matter volume in the anterior cingulate cortex in the left hemisphere in patients with schizophrenia. PMID: 22253779
- Hippocampal activation diminished during the acquisition of contextual fear in healthy carriers of the genome-wide-supported risk variant for schizophrenia, rs12807809 in neurogranin. PMID: 21647148
- our study provides strong evidence that common exonic variation does not account for the genome-wide signi fi cant association between schizophrenia and variation at NRGN PMID: 21538840
- Elevated cerebrospinal fluid neurogranin levels together with Alzheimer disease biomarkers may reflect synaptic degeneration. PMID: 20875798
- No association between the schizophrenia associated NRGN variant rs12807809 and cognition could be detected in these samples. PMID: 21112188
- IL-2 deprivation raises the level of RC3 and other apoptotic factors, which induce apoptosis by increasing the intracellular Ca(2+) concentration PMID: 12808095
- Nevertheless, by gel shift assays, Sp1 and Sp3 were not found to be responsible for the protein-DNA complexes formed by the GC-rich sequence. PMID: 16677608
- Genotype distribution showed association of the rs7113041 SNP with schizophrenia in males of Portuguese origin, which was confirmed by the analysis of the proband-parent triads. PMID: 17140601
- Data suggest that BSX is essential for global cognitive function and that haplo-insufficiency may cause severe mental retardation, and that deletion of Neurogranin contributes to the auditory attention deficit observed in most 11q- patients. PMID: 18855024
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蛋白家族：Neurogranin family
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組織特異性：In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.
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