NR4A1 (Ab-351) Antibody
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中文名稱：NR4A1 (Ab-351)兔多克隆抗體
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貨號：CSB-PA568320
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規格：￥2024
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圖片：
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Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Nuclear Receptor NR4A1 (Ab-351) antibody. -
Western blot analysis of extracts from COS-7 cells, using Nuclear Receptor NR4A1 (Ab-351) antibody. -
Western blot analysis of extracts from HepG2 cells (Lane 2), using Nuclear Receptor NR4A1 (Ab-351) antiobdy. The lane on the left is treated with synthesized peptide.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NR4A1 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized non-phosphopeptide derived from Human Nuclear Receptor NR4A1 around the phosphorylation site of serine 351 (L-P-S(p)-K-P).
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury.
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基因功能參考文獻：
- This study reveals a unique mechanism to suppress hepatocellular carcinoma by switching from glycolysis to gluconeogenesis through Nur77 antagonism of PEPCK1 degradation. PMID: 28240261
- we show here that the BCR/BTK target gene NR4A1 is a potential oncogene in mantle cell lymphoma PMID: 29167454
- this study confirmed that NR4A1 sensitizes gastric cancer cells to TNFalpha-induced apoptosis through the inhibition of JNK/Parkin-dependent mitophagy. PMID: 29207128
- Inhibition of NR4A1 in stromal cells increased the TGF-beta1-dependent elevated expression of fibrotic markers, and loss of NR4A1 stimulated fibrogenesis in mice with endometriosis. PMID: 29669342
- NR4A1 knockdown partly decreased surface NR2B by promoting NR2B internalization. PMID: 27876882
- Data show that SUMOylation is critical in controlling NR4A1 function in inflammatory cytokine signaling and controlling macrophage cell death. PMID: 28622293
- our findings suggest that hypoxia-induced down-regulation of TR3 might play an important role for hypoxia-induced apoptosis resistance in NSCLC. PMID: 28838387
- Nur77 suppresses CD4(+) T cell proliferation and uncover a suppressive role for Irf4 in TH2 polarization; halving Irf4 gene-dosage leads to increases in GATA3(+) and IL-4(+) cells. PMID: 28538176
- our data demonstrated that NR4A1 protein physically associates with the WT1 promoter, and enhanced WT1 promoter transactivation and knockdown of WT1 in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 expression. PMID: 28342843
- NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL) and insulin-like growth factor binding protein-1 (IGFBP-1) expression and transformation in vitro. PMID: 27515096
- DNMT1 causes NR4A1 DNA hypermethylation and blocks insulin signaling in an Chinese patients with type 2 diabetes PMID: 27322146
- Data show that nuclear receptor 4A1 (NR4A1) knockdown and the C-DIM/NR4A1 antagonists were comparable as inhibitors of NR4A1-dependent genes/pathways. PMID: 27144436
- mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed. PMID: 27670690
- NR4A sub-family of nuclear orphan receptors (Nor-1, Nurr-1 and Nur-77) may have a role in trophoblastic cell differentiation. PMID: 28808448
- beta1-integrin expression is regulated in pancreatic and colon cancer cells by the pro-oncogenic orphan nuclear receptor 4A1 PMID: 28418095
- Inhibition of NR4A1-mediated transcriptional activity was involved in the anticancer effects of fangchinoline; fangchinoline represents a novel class of mechanism-based anticancer agents targeting NR4A1 that is overexpressed in pancreatic cancer. PMID: 28754437
- Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 or NR4A1 revealed that apoptosis was driven similarly by induction of BAK, Puma, BIK, BIM, BID, and Trail. Overall, our results showed that NR4A3 possesses robust tumor suppressor functions of similar impact to NR4A1 in aggressive lymphomas PMID: 28249906
- NR4A1 expression is specific to a quiescent subset of T-cells. PMID: 27617863
- we demonstrate that endogenous Nur77 protein expression can serve as a reporter of T-cell receptor and B-cell receptor specific signaling in human peripheral blood mononuclear cells. PMID: 27940659
- we report overexpression of the nuclear receptor NR4A1 in rhabdomyosarcomas that is sufficient to drive high expression of PAX3-FOXO1A PMID: 27864345
- Study found a marked down-regulated gene expression of the NR4A subfamily (NR4A1, NR4A2, and NR4A3) obtained from Parkinson's disease patients, but only a NR4A1 decrease in Alzheimer's disease patients compared to healthy controls. This study reports that the entire NR4A subfamily and not only NR4A2 could be systemically involved in Parkinson's disease. PMID: 27159982
- Nur77 overexpression prevented pulmonary artery smooth muscle cells from proliferation and migration; Nur77 is an important mediator of hypoxia-induced pulmonary vascular remodeling in pulmonary hypertension PMID: 27871853
- Data show Kruppel-like factor 12 (KLF12) impairs endometrial decidualization by transcriptionally repressing Nur77 protein, and Nur77 overexpression reverses the poor decidual response of endometrial stromal cells (hESCs) in recurrent implantation failure (RIF) patients. PMID: 28359310
- Nur77 decreases ET-1 expression by suppressing NF-kappaB and p38 MAPK. PMID: 27765761
- NR4A1 is highly expressed in a subset of HGSOC samples from patients that have a worse progression free survival. PMID: 26946093
- Nur77 gene expression levels might involve different autonomy of ACTH production between Cushing disease (CD) and subCD. PMID: 27025408
- Data show that three TR3 orphan nuclear receptor (TR3) transcript variant messenger RNAs (mRNAs) are expressed in human umbilical vein endothelial cell (HUVEC) and are differentially regulated by vascular endothelial growth factor (VEGF). PMID: 26440050
- Mutagenesis of residues lining the identified interaction site on Bcl-B negated the interaction with Nur77 protein in cells and prevented Nur77-mediated modulation of apoptosis and autophagy PMID: 27129202
- NR4A1 regulates beta1-integrin expression and beta1-integrin-dependent migration of breast cancer cells, and this is accompanied by decreased expression of beta3-integrin. PMID: 26929200
- Data indicate that N-myc downstream regulated gene 1 (NDRG1) competitively bind to glycogen synthase kinase 3beta (GSK-3beta) and orphan nuclear receptor (Nur77) to prevent beta-catenin degradation. PMID: 26359353
- analysis of amino acid fragments required by TR3/Nur77 for its functions in angiogenesis PMID: 26155943
- The results demonstrate that Nur77 is induced by oxLDL via the p38 MAPK signaling pathway, which is involved in the regulation of cell survival. Nur77 enhanced cell survival via suppressing apoptosis, without affecting cell proliferation of activated macrophages, which may be beneficial in patients with atherosclerosis. PMID: 26768365
- NR4As regulate gene transcription primarily through interaction with distal enhancers that are co-enriched for NR4A1 and ETS transcription factor motifs PMID: 26938745
- miR-124 to be downregulated in instances of medulloblastoma in which Nur77 is upregulated, resulting in a proliferative state that abets cancer progression. PMID: 26840408
- ApoA-IV colocalizes with NR4A1, which suppresses G6Pase and PEPCK gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose. PMID: 26556724
- NR4A1 is a key factor in multiple diseases, such as arthritis, inflammation, cancer and cardiovascular diseases. PMID: 25917081
- Identified Nur77/Nor1 as novel regulators of thrombomodulin expression and function in vascular endothelial cells. PMID: 26634653
- The results found that genetic variants of the NUR77 gene are associated with increased risk for both UC and CD PMID: 26564988
- High NR4A1 expression is associated with breast cancer. PMID: 26229035
- Molecular dynamics simulation results of NR4A1 reveal a pronounced pocket that binds the known ligands which is similar to known nucleotide-binding sites. Its molecular conformation can be affected by alternate-site modulators. PMID: 26270486
- Studied the expression and function of TR3 in skin. Also studied the function of TR3 in the effect of androgens in keratinocytes by treating HaCaT keratinocytes and primary human keratinocytes with dihydrotestosterone (DHT) and testosterone (T). PMID: 26707825
- Nur77 protein is expressed in colon tissues from Crohn's disease and ulcerative colitis. Nur77 also strongly decreased expression of MCP-1, CXCL1, IL-8, MIP-1alpha and TNFalpha in gut epithelial Caco-2 cells. PMID: 26241646
- High NR4A1 expression is associated with Renal Cell Adenocarcinoma. PMID: 26035713
- in hepatocytes, HCV core protein increases drug resistance and inhibits cell apoptosis by inhibiting the expressions of NR4A1 and RUNX3 PMID: 26392314
- Results show that Nur77 was overexpressed in high percentage of human colon and liver cancer, and the intracellular location of Nur77 correlated with elevated serum total Bile acids levels in patients with colon cancer. PMID: 25232032
- A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2/9 activity by several mechanisms including the up-regulation of A2M. PMID: 25809189
- In this review, a concise overview of the current understanding of the important metabolic roles governed by NR4A members NR4A1, NR4A2 and NR4A3 including their participation in a number of diseases shall be provided PMID: 25089663
- Data show that some rexinoids display selective coactivator (CoA) recruitment by the retinoid X receptors (RXRs) homodimer and by the heterodimers nuclear receptor Nur77/RXR and Nurr1/RXR. PMID: 26148973
- Histone acetylation contributes to the regulation of NR4A1 expression in hypercholesterolaemia, and that NR4A1 expression reduces hypercholesterolaemia-induced inflammation. PMID: 26396259
- Whereas NR4A1, induced by PDGF-BB, suppresses cell growth on a solid surface, it increases anchorage-independent growth. PMID: 25269081
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亞細胞定位：Nucleus. Cytoplasm. Mitochondrion.
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蛋白家族：Nuclear hormone receptor family, NR4 subfamily
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組織特異性：Fetal muscle and adult liver, brain and thyroid.
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