NPAS1 Antibody

說明書

產品詳情

Uniprot No.：

Q99742
基因名：

NPAS1
別名：

NPAS1 antibody; BHLHE11 antibody; MOP5 antibody; PASD5 antibody; Neuronal PAS domain-containing protein 1 antibody; Neuronal PAS1 antibody; Basic-helix-loop-helix-PAS protein MOP5 antibody; Class E basic helix-loop-helix protein 11 antibody; bHLHe11 antibody; Member of PAS protein 5 antibody; PAS domain-containing protein 5 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the C-terminal region of Human Neuronal PAS1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH.
基因功能參考文獻：
1. Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions. PMID: 28499489
2. Here the authors examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. PMID: 27782878
亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 7894

OMIM: 603346

KEGG: hsa:4861

STRING: 9606.ENSP00000405290

UniGene: Hs.79564

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