NOS1AP Antibody, FITC conjugated
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中文名稱：NOS1AP兔多克隆抗體, FITC偶聯
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貨號：CSB-PA015942LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NOS1AP Polyclonal antibody
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Uniprot No.：
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基因名：NOS1AP
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別名：6330408P19Rik antibody; C terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON) antibody; C terminal PDZ domain ligand of neuronal nitric oxide synthase antibody; C terminal PDZ ligand of neuronal nitric oxide synthase protein antibody; C-terminal PDZ ligand of neuronal nitric oxide synthase protein antibody; CAPON antibody; CAPON_HUMAN antibody; Carboxyl terminal PDZ ligand of neuronal nitric oxide synthase protein antibody; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein antibody; Ligand of neuronal nitric oxide synthase with carboxyl terminal PDZ domain antibody; MGC138500 antibody; Nitric oxide synthase 1 (neuronal) adaptor protein antibody; Nitric oxide synthase 1 adaptor protein antibody; Nos1ap antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (176-288AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4.
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基因功能參考文獻：
- Findings showed that NOS1AP (rs348624, rs12742393 and rs1415263), DISC1 (rs821633 and rs1000731), DAOA (rs2391191) and GSK3B (rs6438552) SNPs had no association with development of early-onset schizophrenia; however, our finding suggested statistically significant role of the interaction of NOS1AP, DISC1, DAOA and GSK3B polymorphisms in schizophrenia susceptibility. PMID: 29100974
- Novel Hispanic/Latino-specific Single Nucleotide Polymorphism at NOS1AP implicate gene regulatory dysfunction in QT prolongation. PMID: 27988371
- If the expression of Capon is decreased, myeloma cells are adhered to fibronectin or bone marrow stromal cells (bone marrow mesenchymal stem cells). In addition, the sensitivity of the cell line to chemotherapeutic agents was reduced after silencing Capon in the myeloma cell line which was adhered to bone marrow mesenchymal stem cells. PMID: 28671047
- sex was identified as a moderator of the association between NOS1AP sequence variants and QTc prolongation in two long QT syndrome founder populations PMID: 28720088
- Association between NOS1AP and PTSD severity, depression, anxiety, and stress was found. NOS1AP was associated with resilience. PMID: 28465168
- gender modulated the interaction between NOS1AP promoter DNA methylation in intracranial aneurysm and brain arteriovenous malformation BAVM patients PMID: 27080431
- results hint towards an involvement of NOS-I/NOS1AP interaction in the regulation of dendritic spine plasticity PMID: 26861996
- Results from genome-wide DNA methylation, functional network analysis and pyrosequencing, show selective CpG sites (NOS1AP, BID, and GABRB1) differentially methylated in smokers and chronic obstructive pulmonary disease patients compared to nonsmokers. PMID: 28416970
- Data indicate that overexpression of nitric oxide synthase 1 adaptor protein short form (CAPON-S) led to the inactivation of the proto-oncogene protein Akt (Akt) signaling pathway. PMID: 27869735
- SNPs in the NOS1AP gene influence QTc interval duration but we have not demonstrated a direct association with the risk of sudden cardiac death PMID: 26332198
- Results suggest that NOS1AP variants are associated with various forms of depression in schizophrenia and are more prevalent in males. PMID: 26384012
- The study suggested that rs3751284 and rs348624 in the NOS1AP gene might be susceptibility loci for sudden unexplained death during daily activities. PMID: 25639344
- report of the association of common NOS1AP polymorphisms with sudden unexplained nocturnal death syndrome in the southern Chinese Han population. These findings suggest that the A allele of rs12567209 and haplotype GCTA may serve as a protective modifier. PMID: 24504561
- The A allele of rs12567209 in NOS1AP may serve as an independent predictor of all-cause death and SCD in patients with CHF. PMID: 24418727
- This study suggested that NOS1 and NOS1AP were associated with schizophrenia. PMID: 24220657
- We further localized NOS1AP to cardiomyocyte intercalated discs (IDs) and demonstrate that overexpression of NOS1AP in cardiomyocytes leads to altered cellular electrophysiology. PMID: 24857694
- This is the first study reporting that a variant of the NOS1AP gene is associated with PTSD. Our data also suggest that a genetic variant in NOS1AP may increase the susceptibility to severe depression in patients with PTSD and increased risk for suicide. PMID: 23146198
- rs10918859 of the NOS1AP gene is associated with CHD in Han Chinese. In addition, here we report a gender effect in the association between rs10918859 of the NOS1AP gene and CHD. PMID: 23171141
- In atherosclerosis, NOS1AP variants were associated with QT in CAU, with weaker evidence for selected variants in HIS and CHN. Location of significant SNPs varied across ancestry. PMID: 23347024
- Decreased NOS1AP expression in rs10494366 TT and rs10918594 CC homozygotes may underlie shorter repolarization times.Myocardial tissue for gene expression analysis was obtained from extracted cardiac implantable electronic device. PMID: 22019493
- Common variations in the NOS1AP gene are associated with a significant increase in the risk of drug-induced long QT syndrome. PMID: 22682551
- NOS1AP colocalizes with both SCRIB and VANGL1 along cellular protrusions in metastatic breast cancer cells, but does not colocalize with either SCRIB or VANGL1 at cell junctions in normal breast cells PMID: 22179838
- Common variations in or near CASQ2, GPD1L, and NOS1AP are associated with increased risk of sudden cardiac death in patients with coronary artery disease PMID: 21685173
- NOS1AP rs203462 polymorphisms did not correlate with an increased risk of QT interval prolongation among kidney recipients. PMID: 21996201
- relationship of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphism with serum creatinine level and occurrence of delayed graft function in kidney transplant recipients PMID: 21959512
- Data show that NOS1AP protein levels are altered in BA46 and cerebellum of patients with schizophrenia. PMID: 20605702
- The genetic variant rs12143842 in NOS1AP is associated with QT interval duration in a Chinese population with Type 2 diabetes. PMID: 20722683
- NOS1AP has a modest effect on ECG t-wave peak to t-wave end interval but is not related to T-wave morphology measures. PMID: 20215044
- the NOS1AP variant is associated with incidence of type 2 diabetes in calcium channel blocker users PMID: 19943157
- Two non-synonymous NOS1AP variations, V37I and D423N were identified in two families, one with two siblings with Obsessive-Compulsive Disorder and the other with two brothers with autism spectrum disorders. PMID: 20602773
- NOS1AP tag SNP genotype may provide an additional clinical dimension, which helps assess risk and choice of therapeutic strategies in LQTS. PMID: 20538168
- NOS1AP variants may not play a dominant role in susceptibility to type 2 diabetes, but a minor effect cannot be excluded. PMID: 19937226
- The length of QT interval verify the importance of NOS1AP protein and to identify a SNP on chromosome 13 reaching genome-wide significance. PMID: 20031603
- Study provided additional evidence for association between genetic variation within NOS1AP and SCD. PMID: 19643915
- these findings support the hypothesis that NOS1 redistribution in injured myocardium requires the formation of a complex with the PDZ adaptor protein CAPON. PMID: 19800018
- Sequence analysis revealed that one non-synonymous substitution in exon 8 was observed in one subject, in addition to six SNPs in exons and introns. This study showed variations in NOS1AP might be involved in occurrence of SIDS PMID: 19289301
- Our findings indicate that CAPON gene may be a candidate susceptibility gene for schizophrenia in Chinese Han population, and also provide further support for the importance of NMDAR-mediated glutamatergic transmission in the etiology of schizophrenia. PMID: 15707951
- study adds support to a role of CAPON in schizophrenia, produces new evidence implicating this gene in the etiology of bipolar disorder, and suggests a possible mechanism of action of CAPON in psychiatric illness PMID: 16146415
- The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations. PMID: 16202394
- This genome-wide study identified NOS1AP (CAPON), a regulator of neuronal nitric oxide synthase, as a new target that modulates cardiac repolarization PMID: 16648850
- NOS1AP variants influence QT interval PMID: 17565224
- Strong effects of NOS1AP variants in diabetic individuals suggest that this patient subset may be particularly susceptible to genetic variants that influence myocardial depolarization and repolarization as manifest in the QT interval. PMID: 18235038
- provide a rationale for the association of CAPON gene variants with extremes of the QT interval in human populations PMID: 18337493
- Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population. PMID: 18430503
- Linkage and association studies from multiple samples drawn from different populations indicate that a schizophrenia susceptibility gene is located in the region of chromosome 1 containing NOS1AP. PMID: 18474209
- Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea. PMID: 18551039
- Single nucleotide polymorphisms are associated with incidence of diabetes mellitus in people who use calcium channel blockers. PMID: 18766325
- Demonstrated that the common NOS1AP variant rs10494366 was associated with increased QT interval in healthy young adults. PMID: 18785031
- A common variant (rs10494366T > G) within NOS1AP gene was associated with QT-interval duration. PMID: 18927126
- study found significant association between eight SNPs in the NOS1AP gene region to schizophrenia (patients from a South American population isolate) and its clinical dimensions PMID: 19077434
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