NLGN4X Antibody
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中文名稱：NLGN4X兔多克隆抗體
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貨號：CSB-PA843131LA01HU
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規格：￥440
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圖片：
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Immunofluorescence staining of Hela cells with CSB-PA843131LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NLGN4X Polyclonal antibody
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Uniprot No.：
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基因名：NLGN4X
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別名：ASPGX2 antibody; AUTSX2 antibody; HLNX antibody; HNL4X antibody; HNLX antibody; KIAA1260 antibody; neuroligin 4, X-linked antibody; Neuroligin X antibody; Neuroligin-4 antibody; NL4 antibody; NLGN antibody; NLGN4 antibody; NLGN4X antibody; NLGNX_HUMAN antibody; OTTHUMP00000022863 antibody; OTTHUMP00000022864 antibody; OTTHUMP00000022865 antibody; X-linked antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Neuroligin-4, X-linked protein (383-494AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，NLGN4X Antibody (CSB-PA843131LA01HU)，的標記方式是Non-conjugated。對于NLGN4X Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IF
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推薦稀釋比：
Application Recommended Dilution IF 1:200-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Putative neuronal cell surface protein involved in cell-cell-interactions.
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基因功能參考文獻：
- NLGN4X might represent novel biomarkers and therapeutic targets for breast cancer. Inhibition of NLGN4X may be a new target for the prevention and treatment of breast cancer PMID: 29244827
- Noncoding polymorphisms on NLGN4X may be associated to autism suggesting the key role of NLGN4X in autism pathophysiology and in its male prevalence. PMID: 27782075
- Endogenous NLGN4X is intensely phosphorylated on T707 upon PKC stimulation in human neurons. PMID: 25675530
- In vitro models show NLGN4X knockdown directly impacts neurodevelopmental process during the formation of neurons and their connections. PMID: 23710042
- Five genes have been directly disrupted in Tourette Syndrome by independent genomic rearrangements and copy number variations with unique breakpoints. PMID: 22948383
- The autism-associated DeltaE4 mutation in NLGN4 compromises the ability of NLGN4 to localize correctly to the cell surface when overexpressed and to induce synaptic differentiation. PMID: 21278334
- results indicate that the genetic variants located in NLGN4 can affect the cognitive abilities of boys. PMID: 20714171
- Results suggest that unique conformational reshaping of the neuroligin 4 surface is required to permit neurexin 1beta association. PMID: 20543817
- finding further contributes to consideration of neuroligins as probable candidate genes for future molecular genetic studies, suggesting that a defect of synaptogenesis may predispose to autism PMID: 19645625
- Scanning and sequencing of 2.5Mb of the NLGN4 genes reveals an association of NLGN4 structural variants at highly conserved amino acids with an estimated attributable risk for autism of about 3% in the cohorts studies. PMID: 15622415
- Data indicate that coding mutations in neuroligin 4 are very rarely associated to autism spectrum disorders. PMID: 16508939
- Splice variants of the NLGN4 gene are associated with autism. PMID: 16648374
- Syntrophin-gamma2 (SNTG2) is a de novo binding partner of X-linked neuroligin 4, which correlates with autism-related mutations. PMID: 17292328
- NLGN4 mutations can be associated with a wide spectrum of neuropsychiatric conditions and that carriers may be affected with milder symptoms PMID: 18231125
- The results suggest a positive association between the genetic variants of the NLGN4 and NSMR in the Chinese children from Qinba Mountains Region. PMID: 19125102
- This study indicated that the phenotypic spectrum of NLGN4X mutations and overexpressed NLGN4X transcript is associated with autism and nonsyndromic mental profound mental retardation. PMID: 19545860
- NLGN4X gene is associated with autistic traits, empathy, and Asperger syndrome. PMID: 19598235
- Two brothers with classical autism spectrum disorder carry a single amino-acid substitution in neuroligin 4 (Arg87Trp). The substitution is absent from the brothers' asymptomatic parents, suggesting that it arose in the maternal germ line. PMID: 19726642
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相關疾病：Autism, X-linked 2 (AUTSX2); Asperger syndrome, X-linked, 2 (ASPGX2)
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density membrane.
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蛋白家族：Type-B carboxylesterase/lipase family
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組織特異性：Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.
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數據庫鏈接：
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