NLGN1 Antibody, HRP conjugated

說明書

中文名稱：

NLGN1兔多克隆抗體, HRP偶聯
貨號：

CSB-PA839786LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NLGN1 Polyclonal antibody
Uniprot No.：

Q8N2Q7
基因名：

NLGN1
別名：

NLG 1 antibody; KIAA1070 antibody; MGC45115 antibody; Neuroligin-1 antibody; NL1 antibody; NLG1 antibody; Nlgn1 antibody; NLGN1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Neuroligin-1 protein (51-300AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. The protein is involved in nervous system development.
基因功能參考文獻：
1. Findings support a contribution of the NLGN1 gene pathway to the neurobiological underpinnings of PTSD. PMID: 27219346
2. We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD PMID: 28841651
3. the expression of NL1 and its binding partner neurexin-1beta was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats. PMID: 25428619
4. Neuroligin 1 (NL1) promotes the formation of glutamatergic synapses and mediates long-term potentiation. PMID: 26440732
5. NLGN1 was associated with schizophrenia in Chinese Han Populations PMID: 26674772
6. Increasing expression of TGF-beta1 protein, decreasing expressions of Ghrelin, Neurexin, and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal PMID: 25399301
7. Neuroligin-1 and Glu may represent new markers of ganglion cells, whose expression may correlate with the pathogenesis, diagnosis, differential diagnosis or classification of Hirschsprung's disease. PMID: 26109803
8. Results indicate that the neurexin and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia. PMID: 26078884
9. Monitoring the attachment and detachment of neurexin (Nrx)-coated quantum dots measures the rates of neurexin (Nrx)/neuroligin interaction in the hippocampus. PMID: 23853109
10. We identified a cluster of single nucleotide polymorphisms at the NLGN1 locus showing significant association with BP variability. Follow-up analyses did not support an association with risk of ischemic stroke and its subtypes PMID: 23929743
11. Expression levels of neurexin and neuroligin in ENS are significantly down-regulated in HSCR, which may be involved in the pathogenesis of HSCR. PMID: 23264101
12. these manipulations of NL1 function illuminate the significance of NL1 intracellular signaling in vivo, and enhance our understanding of the factors that gate the maturation of glutamatergic synapses and complex behavior PMID: 23719805
13. Amyloid beta-peptide binds to the extracellular domain of neuroligin-1 with a K(d) in the nanomolar range. PMID: 21838267
14. glycosylation processing of neuroligin, in addition to mRNA splicing and gene selection, contributes to the specificity of the neurexin-beta/neuroligin-1 association PMID: 14522992
15. the neurexin 1beta/neuroligin 1 complex has a role in synapse formation PMID: 15797875
16. Our discoveries provide insight into the specific interaction of the GOPC PDZ domain with the C-terminal peptide of Nlg and also provide a general insight about the possible binding mode of the interaction of Nlg with other PDZ domain-containing proteins. PMID: 16882988
17. Neuroligin-1 performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities. PMID: 19730411
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cleft. Cell junction, synapse, synaptic cell membrane.
蛋白家族：

Type-B carboxylesterase/lipase family
組織特異性：

Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells.
數據庫鏈接：

HGNC: 14291

OMIM: 600568

KEGG: hsa:22871

STRING: 9606.ENSP00000354541

UniGene: Hs.478289

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