NINL Antibody

說明書

中文名稱：

NINL兔多克隆抗體
貨號：

CSB-PA896492ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA896492ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA896492ESR1HU at dilution of 1:100
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NINL Polyclonal antibody
Uniprot No.：

Q9Y2I6
基因名：

NINL
別名：

NINL antibody; KIAA0980 antibody; NLP antibody; Ninein-like protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ninein-like protein (1-190AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.
基因功能參考文獻：
1. Upon UVC radiation, Nlp interacts with XPA and ERCC1, and enhances their association PMID: 26805762
2. these data support a model where CC2D2A associates with NINL to provide a docking point for cilia-directed cargo vesicles, suggesting a mechanism by which transition zone proteins can control the protein content of the ciliary compartment. PMID: 26485645
3. Overexpression of ninein and the ninein-like protein NIP induces fragmentation of the Golgi and causes lysosomes to disperse toward the cell periphery. PMID: 16254247
4. Breast cancer patients with high expression of Nlp were likely resistant to the treatment of paclitaxel. PMID: 22353935
5. This review summarises our current knowledge of physiological roles of Nlp, with an emphasis on its potentials in tumourigenesis. PMID: 21505454
6. findings demonstrate that Cdc2/cyclin B1 is a key regulator in maintaining appropriate degradation and subcellular localization of Nlp, providing novel insights into understanding on the role of Cdc2/cyclin B1 in mitotic progression PMID: 20890132
7. regulation of Nlp by Aurora B is critical for the completion of cytokinesis, providing novel insights into understanding the machinery of cell cycle progression. PMID: 20864540
8. Nlp abnormalities may contribute to genomic instability and tumorigenesis and might serve as a potential biomarker for clinical diagnosis and as a therapeutic target. PMID: 20093778
9. results indicate that ninein-like protein expression is cell cycle-dependent and regulated by anaphase-promoting cyclosome complex-mediated protein degradation PMID: 17403670
10. Overexpression of Nlp in ovarian tumors raises the possibility that Nlp may play a role in ovarian carcinogenesis. PMID: 18538832
11. Nlp(isoB)interacts with USH2A and lebercilin. PMID: 18826961
12. BRCA1 interaction of Nlp might be required for the successful mitotic progression, and abnormalities of Nlp lead to genomic instability. PMID: 19509300
13. Nlp overexpression might contribute to the development of head and neck squamous cell carcinoma PMID: 19724857
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亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex (PubMed:16254247). During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm (PubMed:16254247).
組織特異性：

Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lun
數據庫鏈接：

HGNC: 29163

OMIM: 609580

KEGG: hsa:22981

STRING: 9606.ENSP00000278886

UniGene: Hs.631508

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