NGEF Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NGEF Polyclonal antibody
Uniprot No.：

Q8N5V2
基因名：

NGEF
別名：

ARHGEF27 antibody; Eph receptor-interacting exchange protein antibody; Eph-interacting exchange protein antibody; EPHEXIN antibody; Ephexin-1 antibody; Guanine nucleotide exchange factor, neuronal antibody; Neuronal guanine nucleotide exchange factor antibody; Ngef antibody; NGEF_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ephexin-1 protein (495-710AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
基因功能參考文獻：
1. A visceral-fat-associated SNP, rs11678490 of NGEF, was found in Korean men. PMID: 26340433
2. FGFR-mediated phosphorylation of ephexin1 enhances the guanine nucleotide exchange activity toward RhoA without affecting the activity to Rac1 or Cdc42. PMID: 17702745
亞細胞定位：

Cytoplasm. Membrane. Cell projection, growth cone.
組織特異性：

Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.
數據庫鏈接：

HGNC: 7807

OMIM: 605991

KEGG: hsa:25791

STRING: 9606.ENSP00000264051

UniGene: Hs.97316

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