NFE2 Antibody
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中文名稱：NFE2兔多克隆抗體
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貨號：CSB-PA015750GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：NFE2
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別名：erythroid-derived 2 45 kDa subunit antibody; Leucine zipper protein NF-E2 antibody; Leucine zipper protein NFE2 antibody; NF E2 antibody; nfe2 antibody; NFE2_HUMAN antibody; Nuclear factor (erythroid derived 2); 45kDa antibody; nuclear factor (erythroid-derived 2); 45kD antibody; Nuclear factor antibody; nuclear factor; erythroid 2 antibody; Nuclear factor; erythroid derived 2 45 kDa subunit antibody; p45 antibody; p45 NF-E2 antibody; p45 NFE2 antibody; Transcription factor NF-E2 45 kDa subunit antibody; Transcription factor NFE2 45 kDa subunit antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human NFE2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
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基因功能參考文獻：
- NF-E2 silencing in hematopoietic stem and progenitor cells (HSPCs) did not affect their myeloid and B cell differentiation in vivo, it almost abrogated T cell production in primary hosts, as confirmed by in vitro studies. This effect is at least partly due to Notch1 downregulation in NF-E2-silenced HSPCs. PMID: 28648895
- results suggest that p45 NF-E2 negatively regulates differentiation and apoptosis activation of human syncytiotrophoblast by modulating GCM1 acetylation and sumoylation. PMID: 28383551
- NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR PMID: 27026582
- under the obese condition, activation of the hepatic NFE2/miR-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A-ATP-Akt signaling pathway. PMID: 28411267
- Our data presented herein support the hypothesis that cytoplasmically located NF-E2 may have a function in the elimination of internal organelles. The mild autophagy defect observed in our mice may be due to the requirement for additional proteins in the formation of larger complexes to exert this function. PMID: 27479815
- assessment of NF-E2 and NGFR expression may provide additional support in reaching a correct diagnosis in discriminating polycythemia vera from prefibrotic/fibrotic primary myelofibrosis and essential thrombocythemia PMID: 26093937
- The genes BCL6, NFE2, POU4F2 and ELF4 are primary 1,25(OH)2D3 targets in THP-1 cells PMID: 25482012
- the RUNX1 target NF-E2 is part of the molecular network by which RUNX1 regulates platelet biogenesis and function in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia PMID: 24606315
- A functional link among the erythroid transcription factors GATA-1/NF-E2, miR-199b-5p in erythropoiesis. PMID: 24608802
- NF-E2 immunohistochemistry and analysis of the proportion of nuclear positive erythroblasts of all erythroid precursor cells can help to distinguish between ET and PMF even in early stages of the diseases. PMID: 24196613
- NFE-2 transgene mediates the expression of interleukin 8 in myeloproliferative neoplasms, thereby contributing to myeloproliferative neoplasm pathology. PMID: 23445878
- IFN-gamma modulates NF-kappaB/c-Jun to antagonize activin A-mediated NF-E2 transcriptional activity on erythroid cell globin gene expression. PMID: 24336657
- RUNX1 and NF-E2 are overexpressed in polycythemic patients of diverse phenotypes and molecular causes PMID: 24297870
- Here we demonstrate that NF-E2 is mislocalized in prefibrotic primary myelofibrosis cells and that aberrant NF-E2 localization discriminates statistically highly significantly between essential thrombocytthemia and that disease. PMID: 23670178
- the role of increased NF-E2 activity in the pathophysiology of myeloproliferative neoplasms, is reported. PMID: 23589569
- NF-E2 overexpression is both required and sufficient for Epo independence and hematopoietic stem cells/myeloid progenitor cell expansion in polycythemia vera. PMID: 23341442
- These findings demonstrate that a combination of p45NF-E2, Maf G, and Maf K is a key determinant of both megakaryopoiesis and thrombopoiesis. PMID: 22855609
- A tissue-specific chromatin loop brings NF-E2 and ANK1E into close proximity preventing gene silencing and mutagenesis leading to hereditary spherocytosis. PMID: 22968456
- Nfe2 modulates JunD binding to the Gcm1 promoter via acetylation PMID: 22174410
- These data establish a role for NF-E2 in the pathophysiology of MPNs and provide a molecular rationale for investigating epigenetic alterations as novel targets for rationally designed MPN therapies. PMID: 22231305
- p45/NF-E2 knockdown inhibited the transcription of the gamma-globin genes, hypersensitive site formation in the LCR and chromatin loop formation of the beta-globin locus. PMID: 21609963
- NLS-dependent nuclear import of p45 NF-E2 is important for platelet development PMID: 20854373
- NF-E2 may play an important role in AHSP gene regulation, providing new insights into the molecular mechanisms underlying the erythroid-specific expression of AHSP as well as new possibilities for beta-thalassemia treatment PMID: 21232177
- data identify NF-E2 as a novel AML1 target gene and delineate a role for aberrant AML1 expression in mediating elevated NF-E2 expression in patients with myeloproliferative neoplasms PMID: 20339092
- USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus. PMID: 20236933
- Data suggest that the posttranslational modifications and turnover of p45/NF-E2, as mediated by P-JNK, contribute to the control of its homeostatic concentration and consequently, its regulatory functions. PMID: 19966288
- p45 dominates over Nrf2 to enhance megakaryocytic maturation by promoting ROS accumulation. PMID: 19901266
- with GATA1, mediates expression of alpha-spectrin gene promoter in erythroid cells in vitro PMID: 12196550
- MafF/NFE2 hetrodimers act as weak transcriptional activators, and, in particular, are able to stimulate activity of the GCS1 promoter. PMID: 12490281
- interaction in the beta-globin locus control regions before chromatin remodeling PMID: 12509425
- IL-1beta up-regulates expression in megakaryocytic cells PMID: 14966463
- model of mammalian beta-like globin gene activation by sumoylated p45/NF-E2 in erythroid cells PMID: 16287851
- Scl acts up-stream of NF-E2 expression to control megakaryocyte development and platelet release in settings of thrombopoietic stress PMID: 16763211
- This is the first in vivo evidence for the interaction between p45/NF-E2 and the E3 ubiquitin ligase Itch, and the subsequent ubiquitination of p45/NF-E2 by Itch. PMID: 18718448
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亞細胞定位：Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
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蛋白家族：BZIP family, CNC subfamily
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組織特異性：Expressed in hematopoietic cells and also in colon and testis.
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