NEUROG3 Antibody
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中文名稱：NEUROG3兔多克隆抗體
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貨號：CSB-PA956774
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規(guī)格：￥2024
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圖片：
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Gel: 12%SDS-PAGE Lysates (from left to right): Mouse liver tissue Amount of lysate: 50μg per lane Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 40 seconds -
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NEUROG3 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Full length fusion protein
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.
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基因功能參考文獻：
- novel homozygous nonsense mutation (p.Q4*) as the genetic cause of neonatal diabetes mellitus and severe malabsorptive diarrhea in 2 cousins PMID: 28940958
- PDX1, Neurogenin-3, and MAFA are critical transcription regulators for beta cell development and regeneration. (Review) PMID: 29096722
- Sox9 and Ngn3, key transcription factors associated with pancreatic development. PMID: 27836003
- This reviews the expression and function of NEUROG3 in both mouse and human pancreatic development. [Review Article] PMID: 27615127
- Neurogenin3 controls its ability to promote pancreatic endocrine differentiation and to maintain beta cell function in the presence of pro-proliferation cues PMID: 28457793
- Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors PMID: 28441528
- Collectively, our results demonstrate that the STAT3(K392R) mutation causes premature endocrine differentiation through direct induction of NEUROG3 expression. PMID: 28402852
- inflammatory cytokine insults stimulate epithelial-to-mesenchymal transition (EMT) as well as the endocrine program in human pancreatic ductal cells via STAT3-dependent NGN3 activation. PMID: 27068459
- ChIP experiments confirmed that Pdx1 activates the expression of the downstream transcription factors, Ngn3 and Pax6, by combined with the promoter regions of insulin (Insulin-P), Ngn3 (Ngn3-P), and Pax6 (Pax6-P). PMID: 26345820
- NGN3 expression in the adult human exocrine pancreas marks a dedifferentiating cell population. PMID: 26288179
- conclude that NEUROG3 is essential for endocrine pancreas development in humans and that as little as 10% NEUROG3 is sufficient for formation of pancreatic endocrine cells PMID: 25650326
- NEUROG3 deficiency produces a rare clinical syndrome characterised by severe malabsorptive diarrhoea from early life and mild diabetes with a variable age of onset. PMID: 25120094
- Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury. PMID: 24925797
- The expression of transcription factor Ngn3 and pancreatic mesenchymal microenvironment are important and necessary to promote pancreatic progenitors differentiated to islet cells regardless of pancreatic development or islets regeneration. PMID: 24969979
- Recessively inherited NEUROG-3 mutations were originally identified in three patients with unexplained congenital malabsorptive diarrhea and an absence of EC. PMID: 24134759
- Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells. PMID: 24493854
- Data indicate associations of SNPs in eight loci CXCR4, HHEX, FOXA2, NGN3, TCF7L2, FLJ39370 (C4orf32), LOC646279 (RPL21P7) and THADA with body mass index (BMI) and weight. PMID: 23349771
- Ngn3-mediated pancreatic duct-to-endocrine cell reprogramming was measured employing genome wide mRNA profiling. PMID: 22606327
- CCAR1 is a novel partner of Ngn3 in mediating endocrine differentiation. PMID: 22266316
- The variants in HNFA and NEUROG3 indicate a strong predisposition of normal-weight/lean subjects to T2D in North Indians. PMID: 21814221
- Gastrin-positive neuroendocrine tumors, whether of duodenal or pancreatic origin, frequently expressed PDX1 (17/18), ISL1 (14/18), and NGN3 (14/18). PMID: 21739268
- Severe deficiency of neurogenin 3 causes a rare novel subtype of permanent neonatal diabetes. This finding confirms the essential role of NEUROG3 in islet development and function in humans PMID: 21378176
- Ngn3-Cre-based lineage tracing showed that pdx-1-expressing cells differentiated to all the types of pancreatic cells, while Ngn3 marked endocrine-specific progenitors. PMID: 20668890
- The important role of Ngn3 as a master regulator of endocrine pancreas development directs attention to finding therapeutic approaches to enhance Ngn3 expression in diabetes as a means to increase beta cell mass and functions. PMID: 21099270
- These results support an important inter-species difference in regulating insulin exocytosis where RAB3B is the most expressed isoform in human islets. PMID: 20807725
- mutations of NEUROG3 gene are not a common cause of neonatal/infancy/childhood-onset diabetes PMID: 19538245
- adult human pancreatic duct cells can be converted into insulin-expressing cells after ectopic, adenovirus-mediated expression of the class B basic helix-loop-helix factor neurogenin 3 PMID: 12403815
- Polymorphism contributes to glucose intolerance in a South Indian population. PMID: 15277395
- The Notch/Ngn3 signalling network is intact and functional in adult islets. PMID: 17922104
- A genetic variation in the NGN3 gene may be among the genetic determinants involved in the pathogenesis of diabetes. PMID: 18072012
- Tumors and MEN1 nontumorous endocrine cells showed a prominent cytoplasmatic NEUROG3 and NEUROD1 expression PMID: 19307926
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相關疾?。?/div>Diarrhea 4, malabsorptive, congenital (DIAR4)亞細胞定位：Nucleus.數(shù)據(jù)庫鏈接：
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