NEK11 Antibody, HRP conjugated
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中文名稱：NEK11兔多克隆抗體, HRP偶聯
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貨號：CSB-PA844052LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NEK11 Polyclonal antibody
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Uniprot No.：
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基因名：NEK11
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別名：4932416N14Rik antibody; FLJ23495 antibody; NEK11 antibody; NEK11_HUMAN antibody; NEK11S/L antibody; Never in mitosis A-related kinase 11 antibody; NIMA (never in mitosis gene a) related kinase 11 antibody; NIMA (never in mitosis gene a)- related kinase 11 antibody; NIMA related kinase 11L antibody; NIMA related kinase 11S antibody; NIMA-related kinase 11 antibody; NimA-related protein kinase 11 antibody; Serine/threonine-protein kinase Nek11 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Serine/threonine-protein kinase Nek11 protein (245-482AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
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基因功能參考文獻：
- contributes to response of colorectal cancer cells to genotoxic agents and is essential for survival either with or without exposure to DNA damage PMID: 26501353
- Results show that downregulation of NEK11 in drug resistant cells might contribute to drug resistance in ovarian cancer. PMID: 24969318
- NEK11 controls degradation of CDC25A by directly phosphorylating CDC25A on residues whose phosphorylation is required for beta-TrCP mediated CDC25A polyubiquitylation and degradation. PMID: 20090422
- Nek11 has a role in the S-phase checkpoint downstream of the caffeine-sensitive pathway PMID: 12154088
- Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells PMID: 15161910
- NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. PMID: 19734889
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亞細胞定位：Nucleus. Nucleus, nucleolus.
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蛋白家族：Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
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組織特異性：Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
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數據庫鏈接：
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