NEBL Antibody, FITC conjugated
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中文名稱：NEBL兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA015673LC01HU
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規(guī)格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NEBL Polyclonal antibody
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Uniprot No.：
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基因名：NEBL
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別名：NEBL antibody; LNEBLNebulette antibody; Actin-binding Z-disk protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Nebulette protein (438-533AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion.
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基因功能參考文獻：
- Survival analysis suggested that overexpressed NEBL in patients with colorectal cancer was associated with a positive prognosis for overall survival. PMID: 29257257
- LASP2 may play a significant role in suppressing CRC progression and provided a novel biomarker for CRC therapy PMID: 28606091
- The levels of phosphorylated FAK (Tyr397 and Tyr925) were increased after overexpressing Lasp2 and were downregulated by transfecting Lasp2-siRNA. PMID: 28667800
- predisposition to multibacillary leprosy in Vietnam is associated with CUBN and NEBL common variants in the chromosome 10p13 linkage region PMID: 24563210
- We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2 PMID: 23985323
- Data indicate that lasp-2 interacts with the focal adhesion proteins vinculin and paxillin. PMID: 23389630
- Report oncogenic potential of MLL-NEBL and NEBL-MLL fusion genes in acute myeloid leukemia. PMID: 23340173
- Different mutations in nebulette transgene trigger a pathological cascade leading to endocardial fibroelastosis and dilated cardiomyopathy in mutant embryonic mouse hearts. PMID: 20951326
- our data demonstrate the importance of this cardiac-specific nebulin isoform in myofibril organization and function. Our data demonstrate that nebulette plays a significant role in the structure and stability of the cardiac Z-line. PMID: 11822876
- LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions PMID: 15004028
- filamin-C, a known component of striated muscle Z-lines, interacts with nebulette modules PMID: 17987659
- the importance of the nebulette-TPM interactions in the maintenance and stability of the thin filaments. PMID: 18823973
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亞細胞定位：[Isoform 2]: Cytoplasm.
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組織特異性：Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in fibroblasts.
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