NASP Antibody

說明書

中文名稱：

NASP兔多克隆抗體
貨號：

CSB-PA015462DSR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA015462DSR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA015462DSR1HU at dilution of 1:100
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NASP Polyclonal antibody
Uniprot No.：

P49321
基因名：

NASP
別名：

5033430J04Rik antibody; AI131596 antibody; AI317140 antibody; D4Ertd767e antibody; DKFZp547F162 antibody; Epcs32 antibody; FLB7527 antibody; FLJ31599 antibody; FLJ35510 antibody; MGC19722 antibody; MGC20372 antibody; MGC2297 antibody; MGC93869 antibody; NASP antibody; NASP_HUMAN antibody; nuclear autoantigenic sperm protein (histone binding) antibody; Nuclear autoantigenic sperm protein antibody; PRO1999 antibody; RP23 233B9.9 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nuclear autoantigenic sperm protein (519-788AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
基因功能參考文獻：
1. NASP is targeted by miR-29c in gastric cancer cells. miR-29c can decrease NASP expression and the effects observed following miR-29c overexpression are partially due to NASP depletion. PMID: 28173777
2. findings reveal a new mode of interaction between a TPR repeat domain of histone chaperone sNASP and an evolutionarily conserved peptide motif found in canonical H3 and in all histone H3 variants PMID: 26673727
3. Our research demonstrates that knockdown of tNASP effectively inhibits the proliferation and causes G1 phase arrest through ERK/MAPK signal pathway. PMID: 25669170
4. These results provide evidence that tNASP is ubiquitously produced in various types of human tissues and promotes in vitro nucleosome assembly with H3 variant specificity. PMID: 25615412
5. NASP family Proteins are highly conserved throughout the eukaryotes and posses four TPR motifs. It was likely present in the last common ancestor of eukaryotes possibly representing an important innovation regarding H3/H4 transport mechanism. Different TPR motifs in NASP have evolved at different rates with TPR1/4 evolving faster than TPR2/3. PMID: 24951090
6. Studies indicate that histone chalerones nucleoplasmin (NPM2/NPM3) preferentially associated with histones H2A-H2B in the egg and the nuclear autoantigenic sperm protein (NASP) families. PMID: 22968912
7. an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development. PMID: 22194605
8. sNASP interacts with linker and core histones through distinct structural domains. PMID: 21965532
9. The insights into NASP function and the existence of a tunable reservoir in mammalian cells demonstrate that contingency is integrated into the histone supply chain to respond to unexpected changes in demand. PMID: 22195965
10. tNASP is critical for the survival of prostate cancer cells; targeting tNASP expression can lead to a new approach for prostate cancer treatment. PMID: 21496299
11. NASP and RCAS1 proteins were more frequently expressed in ovarian cancer tissues than with normal ovarian tissue and serous cystadenomas and MRE11 was less frequently expressed PMID: 20164540
12. A deletion analysis of sNASP revealed that the central region, amino acid residues 26-325, of sNASP is responsible for nucleosome assembly in vitro. PMID: 20167597
13. NASP and the linker histones are key players in the assembly of chromatin after DNA replication PMID: 16728391
14. NASP forms distinct, high specificity complexes with histones H3 and H4. PMID: 18782834
15. NASP belongs to a network of genes and gene functions that are critical for cell survival PMID: 19439102
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

NASP family
組織特異性：

Isoform 1 is testis- and sperm-specific.
數據庫鏈接：

HGNC: 7644

OMIM: 603185

KEGG: hsa:4678

STRING: 9606.ENSP00000255120

UniGene: Hs.319334

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