NAPRT Antibody, FITC conjugated

說明書

中文名稱：

NAPRT兔多克隆抗體, FITC偶聯
貨號：

CSB-PA015451EC01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NAPRT Polyclonal antibody
Uniprot No.：

Q6XQN6
基因名：

NAPRT
別名：

FHA HIT interacting protein antibody; FHA-HIT-interacting protein antibody; FHIP antibody; NAPRT1 antibody; NAPRTase antibody; Nicotinate phosphoribosyltransferase antibody; Nicotinate phosphoribosyltransferase domain containing 1 antibody; Nicotinate phosphoribosyltransferase domain-containing protein 1 antibody; Nicotinic acid phosphoribosyltransferase antibody; PNCB_HUMAN antibody; PP3856 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nicotinate phosphoribosyltransferase protein (1-310AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
基因功能參考文獻：
1. No correlation between IDH1/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma PMID: 28860121
2. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases PMID: 28416276
3. High NAPRTase expression is associated with neoplasms. PMID: 26675378
4. Tumor-specific promoter hypermethylation of NAPRT1 inactivates one of two NAD salvage pathways, resulting in synthetic lethality with the coadministration of a NAMPT inhibitor. PMID: 24097869
5. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner PMID: 22570471
6. NAPRT expression was varied in lymphomas with 30-50% low expression except for Hodgkin's lymphoma where 85% displayed low expression PMID: 21492230
7. NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD PMID: 17604275
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亞細胞定位：

Cytoplasm, cytosol.
蛋白家族：

NAPRTase family
數據庫鏈接：

HGNC: 30450

OMIM: 611552

KEGG: hsa:93100

STRING: 9606.ENSP00000401508

UniGene: Hs.493164

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