N4BP1 Antibody

中文名稱(chēng)：

N4BP1兔多克隆抗體
貨號(hào)：

CSB-PA003360
規(guī)格：

￥1090
圖片：
Western Blot analysis of K562 cells using N4BP1 Polyclonal Antibody

Western Blot analysis of K562 cells using N4BP1 Polyclonal Antibody
其他：

產(chǎn)品詳情

Uniprot No.：

O75113
基因名：

N4BP1
別名：

FLJ31821 antibody; KIAA0615 antibody; MGC176730 antibody; N4BP1 antibody; N4BP1_HUMAN antibody; NEDD4 binding protein 1 antibody; NEDD4-binding protein 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human N4BP1.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, IHC, ELISA

推薦稀釋比：

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines. Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity. Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates.
基因功能參考文獻(xiàn)：
1. The p34 interacts with the WW1 domain of NEDD4-1, an interaction that enhances NEDD4-1 stability. PMID: 24141722
亞細(xì)胞定位：

Cytoplasm, cytosol. Nucleus. Nucleus, nucleolus. Nucleus, PML body.
蛋白家族：

N4BP1 family
組織特異性：

Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and ovary.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 29850

KEGG: hsa:9683

STRING: 9606.ENSP00000262384

UniGene: Hs.511839

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