Mlc1 Antibody

文獻引用 (1) 說明書

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Mlc1 Antibody Polyclonal antibody
Uniprot No.：

Q8VHK5
基因名：

Mlc1 Antibody
別名：

Membrane protein MLC1, Mlc1
宿主：

Rabbit
反應種屬：

Mus musculus (Mouse)
免疫原：

Recombinant Mus musculus (Mouse) Mlc1 protein (331-382aa)
免疫原種屬：

Mus musculus (Mouse)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Modulator of VRAC current 1 is a potential target antigen in multiple sclerosis JR Dahl, A Weier, C Winter, M Hintze,Neurology-Neuroimmunology & Neuroinflammation,2025

功能：

Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.
基因功能參考文獻：
1. Mlc1 overexpression reduced activity of the astrocytic sodium pump, which may underlie white matter edema followed by myelin membrane splitting PMID: 27748972
2. This study demonistrated that Mlc1-null mice replicate the human with megalencephalic leukoencephalopathy with cysts. PMID: 25382142
3. The complete cDNA sequence, exon-intron organization, and 5'-flanking regulatory region of murine Mlc1 have been reported. PMID: 12658361
4. Because the temporal expression of Mlc1 indicates that, in contrast to developing and mature astrocytes, oligodendrocytes are devoid of Mlc1 expression, white matter tract abnormalities in these disorders may result from a primary astrocytic defect. PMID: 14603469
5. Wkl1 is not associated with schizophrenia. PMID: 14755440
6. Localization and functional analysis of Mlc1 were done in megalocephalic leukoencephalopathy with subcortical cysts. PMID: 15367490
7. Our data provide a mouse MLC1 expression map that could be useful to understand the phenotype of MLC patients, and suggested that MLC disease is caused by an astrocytic and a neuronal dysfunction PMID: 17434314
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亞細胞定位：

Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasm, perinuclear region. Endoplasmic reticulum.
數據庫鏈接：

KEGG: mmu:170790

STRING: 10090.ENSMUSP00000047667

UniGene: Mm.32780

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