Mgll Antibody

^{Rare Species}

中文名稱：

Mgll兔多克隆抗體
貨號：

CSB-PA013787LA01RA
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat lung tissue, Mouse brain tissue
All lanes: Mgll antibody at 2.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 34 kDa
Observed band size: 34 kDa
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Rattus norvegicus (Rat) Mgll Polyclonal antibody
Uniprot No.：

Q8R431
基因名：

Mgll
別名：

Mgll antibody; Mgl2 antibody; Monoglyceride lipase antibody; MGL antibody; EC 3.1.1.23 antibody; Monoacylglycerol lipase antibody; MAGL antibody
宿主：

Rabbit
反應種屬：

Rat, Mouse
免疫原：

Recombinant Rat Monoglyceride lipase protein (1-303AA)
免疫原種屬：

Rattus norvegicus (Rat)

標記方式：

Non-conjugated

本頁面中的產品，Mgll Antibody (CSB-PA013787LA01RA)，的標記方式是Non-conjugated。對于Mgll Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA013787LB01RA	Mgll Antibody, HRP conjugated	ELISA
FITC	CSB-PA013787LC01RA	Mgll Antibody, FITC conjugated
Biotin	CSB-PA013787LD01RA	Mgll Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
基因功能參考文獻：
1. 4 weeks of post-weaning social isolation increased aggressive grooming of a novel same-sex conspecific in male and female rats. Treatment with the MAGL inhibitor MJN110 eliminated this increase in aggressive grooming in both males and females, without reducing non-aggressive social behavior. Activation of the medial prefrontal cortex was increased by social interaction but was blunted by MJN110 only in females. PMID: 29292159
2. MGL has an important role in insulin secretion PMID: 26867016
3. expression of MAGL is distributed in certain cell types and time-dependently expressed in skeletal muscles after trauma, suggesting that MAGL may be involved in inflammatory response, fibrogenesis and regeneration during skeletal muscle wound healing PMID: 25921063
4. MAGL inhibitor JZL184 is able to inhibit the inflammatory response and interfere with contused muscle healing. PMID: 25912803
5. results suggest that MAGL regulates phagocytosis, but not LPS-mediated cytokine induction in microglia PMID: 26166819
6. the current findings support the therapeutic potential of FAAH and monoacylglycerol lipase inhibitors as a novel pharmacotherapy for pain PMID: 25041240
7. Data indicate that nerve growth factor (NGF) controls monoacylglycerol lipase (MGL) degradation in vitro and in vivo. PMID: 23319656
8. Pretreatment with MAGL inhibitor URB602 significantly reduces neonatal hypoxic-ischemic brain damage and improves functional outcome. PMID: 22821058
9. Maternal deprivation induced a significant decrease in MAGL immunoreactivity in the rat hippocampal CA3 and CA1 areas, more marked in males than in females. PMID: 20599824
10. hydrolysis by means of monoglyceride lipase is a primary mechanism for 2-arachidonoylglycerol inactivation in intact neurons PMID: 12136125
11. MGL is localized in the enteric nervous system where endocannabinoids regulate intestinal motility. MGL is highly expressed in the epithelium, where this enzyme may have digestive or other functions yet to be determined. PMID: 18948437
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亞細胞定位：

Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
蛋白家族：

AB hydrolase superfamily, Monoacylglycerol lipase family
組織特異性：

Ubiquitous. Highly expressed in adipose tissue, adrenal gland, ovary, heart, spleen, lung, skeletal muscle, kidney and testis. Highly expressed throughout the brain.
數據庫鏈接：

KEGG: rno:29254

STRING: 10116.ENSRNOP00000030271

UniGene: Rn.40396

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