MZF1 Antibody

說明書

中文名稱：

MZF1兔多克隆抗體
貨號：

CSB-PA915557
規格：

￥2024
圖片：
Western blot analysis of extracts from 293 cells and K562 cells, using MZF-1 antibody.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using MZF-1 antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MZF1 Polyclonal antibody
Uniprot No.：

P28698
基因名：

MZF1
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from N-terminal of Human MZF-1.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.
基因功能參考文獻：
1. Mechanistically, FTO enhanced MZF1 expression by reducing m(6)A levels and mRNA stability in MZF1 mRNA transcript, leading to oncogenic functions. PMID: 29842885
2. MZF1 gene expression was not significantly correlated with PYROXD2 protein expression in the samples of resected tumor tissues, which revealed that the PYROXD2 promoter transcription activity was determined by the aggregated effect of numerous transcription factors. This finding may be helpful in understanding the underlying mechanism which regulates the PYROXD2 expression. PMID: 29048625
3. PAX2 is involved in the carcinogenesis of endometrial cancer by stimulating cell growth and promoting cell motility; the overexpression of PAX2 in endometrial cancer is regulated by promoter hypermethylation and the transcription factor MZF1 PMID: 27764784
4. miR-337-3p directly binds to the MMP-14 promoter to repress MZF1-facilitatd MMP-14 expression, thus suppressing the progression of gastric cancer PMID: 27259238
5. TGF-beta1-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway. PMID: 28703907
6. SIRT6 over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 promoter chromatin structure makes it receptive to interaction with MZF1/SIRT6 complex, thereby favouring a regulatory state conducive to diminished transcription PMID: 28478957
7. Tumor antigen PRAME is up-regulated by MZF1 in cooperation with DNA hypomethylation in melanoma cells. PMID: 28634046
8. MZF1 has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1-SMAD4 axis, a new therapeutic target in advanced human gastric cancer. PMID: 27922669
9. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation PMID: 25903835
10. These findings suggest that PKCalpha expression in HCC could be stimulated by the formation of MZF-1/Elk-1 complex, which directly binds to the PKCalpha promoter. PMID: 26010542
11. our results revealed that the loss of nuclear expression of MZF1 in oral squamous cell carcinoma (OSCC) samples can predict the progression of OSCC and the survival of OSCC patients in Taiwan PMID: 25877752
12. The aberrant decreases in Ik-1 and MZF1 contribute significantly to the pathogenesis of NPM-ALK(+) T-cell lymphoma through the upregulation of IGF-IR expression. PMID: 25884514
13. our results argue that MZF-1 regulates the CTGF and NOV genes in the hematopoietic compartment, and may be involved in their respective functions in the stroma. PMID: 25899830
14. Data indicate that elevated miR-492 expression in prostate tumors that resulted in diminished myeloid zinc-finger 1 (MZF-1) and ferroportin (FPN). PMID: 25284586
15. Data suggest that induction of foxhead box M1(FOXM1) by E6 oncoprotein through the transcription factors MZF1/NKX2-1 axis may be responsible for human papillomavirus 16/18-mediated tumor progression. PMID: 25425970
16. MZF1-mediated MYC expression may promote tumor progression, resulting in poor outcomes in cases of lung adenocarcinoma with low-wild-type-LKB1 tumors. PMID: 24793789
17. MZF-1 binds to and positively regulates the GAPDH promoter. PMID: 25065746
18. p55PIK is transcriptionally activated by MZF1, resulting in increased proliferation of colorectal cancer cells PMID: 23509792
19. Selected single nucleotide polymorphisms in the MZF-1 gene exert a minor effect on the risk of Alzheimer's disease. PMID: 23241556
20. This study shows that MZF-1 represses MMP-2 transcription and suggests that this repression may be linked to inhibition of human cervical cancer cell migration and metastasis. PMID: 22846578
21. Expression levels of Elk-1 and PKCalpha were the highest in 5637 cells, but the MZF-1 expression observed in all five cell lines showed no significant difference. PMID: 22559731
22. signaling network activates the transcription of cathepsin B gene via myeloid zinc finger-1 transcription factor that binds to an ErbB2-responsive enhancer element in the first intron of cathepsin B PMID: 22464443
23. association between the expression of PKCalpha and the expression of the transcription factors Elk-1 and MZF-1 in breast cancer cell lines PMID: 22242952
24. Taken together, this is the first study to show that MZF1 induces invasion and in vivo metastasis in colorectal and cervical cancer, at least in part by regulating Axl gene expression. PMID: 20145042
25. MZF-1 and FHL3 formed a complex of high molecular mass with some additional proteins in the nucleus. Transcriptional repression of FcepsilonRI by MZF-1 required FHL3 as a cofactor. PMID: 15453830
26. Sp1 and MZF1 are involved in the transcriptional regulation of the hST6GalNAc IV gene in Jurkat T cells PMID: 15528990
27. MZF1 are important transcription factors regulating N-cadherin promoter activity and expression in osteoblasts. PMID: 15541732
28. a transcription factor, MZF-1, was revealed to interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis PMID: 15670815
29. PKCalpha expression may be modulated by Elk-1 and MZF-1 at the transcriptional level. PMID: 16297876
30. Structure of MZF1 SCAN domain homodimer has been determined and provides an initial view of the recognition elements that govern dimerization for this large family of transcription factors. PMID: 16950398
31. MZF1 and Sp1/Sp3 binding to the promoter region drive the PADI1 expression in keratinocytes PMID: 17851584
32. These data suggest that APO can enhance the biosynthesis and release of FGF-2 through the activation of the MZF-1 transcription factor in striatal astrocytes PMID: 19196427
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亞細胞定位：

Nucleus.
蛋白家族：

Krueppel C2H2-type zinc-finger protein family
組織特異性：

Preferentially expressed in differentiating myeloid cells. Detected in osteoblasts.
數據庫鏈接：

HGNC: 13108

OMIM: 194550

KEGG: hsa:7593

STRING: 9606.ENSP00000215057

UniGene: Hs.399810

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