MYPN Antibody
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中文名稱：MYPN兔多克隆抗體
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貨號：CSB-PA015378GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MYPN
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別名：145 kDa sarcomeric protein antibody; MYOP antibody; Myopalladin antibody; MYPN antibody; MYPN_HUMAN antibody; sarcomeric protein myopalladin antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MYPN-Specific
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
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基因功能參考文獻：
- Targeted sequencing revealed trigenic mutations: c.700G>A/p.E234K in DES, c.2966G>A/p.R989H in MYPN, and c.5918G>C/p.R1973P in CACNA1C in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome. PMID: 28427417
- Homozygous truncating mutations in MYPN in 2 unrelated families with a slowly progressive congenital cap myopathy. PMID: 28220527
- results suggest that MYPN screening should be considered in individuals with mild nemaline myopathy, especially when cardiac problems or intranuclear rods are present PMID: 28017374
- Heterozygote Mypn(WT/Q526X) knock-in mice develop RCM due to persistence of mutant Mypn(Q526X) protein in the nucleus. PMID: 25541130
- the clinical significance of myopalladin for the functional integrity of the sarcomeric apparatus and the protection against dilated cardiomyopathy PMID: 22892539
- Two nonsense and 13 missense MYPN variants were identified in subjects with hypertrophic, dilated and/or restrictive cardiomyopathy. PMID: 22286171
- mutations in PDLIM3 and MYPN are infrequent in hypertrophic cardiomyopathies PMID: 20801532
- myopalladin plays a signaling role in targeting and orienting nebulin during sarcomere assembly PMID: 12482578
- myopalladin gene is a new gene associated with dilated cardiomyopathy and observed mutations in 3-4% of cases in a population. of European descent. PMID: 18006477
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相關疾病：Nemaline myopathy 11 (NEM11); Cardiomyopathy, dilated 1KK (CMD1KK); Cardiomyopathy, familial hypertrophic 22 (CMH22); Cardiomyopathy, familial restrictive 4 (RCM4)
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亞細胞定位：Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line.
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蛋白家族：Myotilin/palladin family
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組織特異性：Expressed in adult skeletal muscle and fetal heart.
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數據庫鏈接：
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