MYOCD Antibody

說明書

中文名稱：

MYOCD兔多克隆抗體
貨號：

CSB-PA015357GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q8IZQ8
基因名：

MYOCD
別名：

MYCD antibody; MYCD_HUMAN antibody; Myocardin antibody; Myocd antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human Myocd
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis).
基因功能參考文獻：
1. Study shows that vascular endothelial growth factor A stimulates STAT3 activity via nitrosylation of myocardin to regulate the expression of vascular smooth muscle cell differentiation markers. PMID: 28572685
2. conditional knockout models have revealed a critical role for myocardin during cardiac chamber maturation, and a surprising function for myocardin in the regulation of cardiomyocyte proliferation, cell death, and possibly mitochondrial function. PMID: 28631251
3. YAP negatively regulates differentiation of Vascular smooth muscle cells (VSMCs) derived from cardiovascular progenitor cell (CVPC) by decreasing transcription of myocardin in a NKX2.5-dependent manner. PMID: 27571517
4. Myocardin inhibits estrogen receptor alpha-mediated proliferation of human breast cancer cells via regulating MicroRNA expression. PMID: 27156566
5. Key role for miR-214 in modulation of MEF2C-MYOCD-LMOD1 signaling. PMID: 27144530
6. Study demonstrates that myocardin indirectly down-regulates Cx43 through its repressive action on miR-206 to regulate vascular smooth muscle cell phenotypic switch. PMID: 28342807
7. These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity. PMID: 27403897
8. our study reveals that Ang II downregulates miR-145 to regulate Klf4 and myocardin expression in HCASMCs under high glucose conditions. Ang II plays a critical role in the regulation of miR-145 under hyperglycemic conditions PMID: 26181633
9. Human expression data disclosed correlations of MYOCD with CAV1 in a majority of human tissues and in the heart, correlation with MKL2 (MRTF-B) was observed. PMID: 26244347
10. inhibition of GSK-3beta reduces myocardin transcriptional activity, suggesting a role for GSK-3beta in myocardin transcriptional activity and smooth muscle differentiation PMID: 26129946
11. STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin and SRF. PMID: 26100622
12. TNFalpha differentially regulates myocardin expression and activity PMID: 25384061
13. Propose myocardin as a guardian of the contractile, noninflammatory VSMC phenotype, with loss of myocardin representing a critical permissive step in the process of phenotypic transition and inflammatory activation, at the onset of vascular disease. PMID: 25614278
14. it is probably that miR135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin PMID: 25190111
15. Early cardiac marker gene myocardin levels in peripheral blood mononuclear cells reflect severity in stable coronary artery disease. PMID: 24681789
16. Myocardin meditates apoptosis in breast cancer through affecting maspin re-expression and epigenetic modification. PMID: 24607789
17. the first evidence demonstrating that TEAD1 is a novel general repressor of smooth muscle-specific gene expression through interfering with myocardin binding to SRF. PMID: 24344135
18. ChIP analysis established that PDGF-BB-induced repression of Myocd gene expression is most likely regulated by enhanced binding of Klf4 and Klf5 to a lesser extent, to the PRR of PrmM PMID: 24060351
19. Myocardin increases the development and maturation of smooth muscle cell-like cells from human embryonic stem cells despite not activating the full repertoire of smooth muscle cell genes. PMID: 22937150
20. Hypertension negates the activity of myocardin in vascular smooth muscle cells. PMID: 22843699
21. Nuclear uPAR associates with myocardin, which is then recruited from the promoters of serum response factor target genes and undergoes proteasomal degradation. PMID: 22075245
22. Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. PMID: 21984848
23. Vascular smooth muscle proteasomal degradation of myocardin is required for its transcriptional activity. PMID: 21506120
24. Epigenetic inactivation of Myocardin is a frequent and tumor-specific event in nasopharyngeal carcinoma. PMID: 20848417
25. Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. PMID: 21051663
26. A positive association was observed between response to methadone and two variants in the genes MYOCD and GRM6. PMID: 20560679
27. These findings suggest a role of microRNA-1 in the negative feedback loop in the regulation of smooth muscle contractility induced by myocardin. PMID: 20458751
28. These results are the first to show relative expression and activities of the major myocardin isoforms across disparate spec PMID: 20385216
29. Results indicate that the downregulation of myocardin expression facilitates cell cycle progression via the reduction of p21 expression in human leimyosarcomas PMID: 20068148
30. the evaluation of myocardin expression is useful in distinguishing uterine smooth muscle tumors from endometrial stromal sarcomas PMID: 19952936
31. Myocardin was identified as a novel gene upregulated in human cervical ripening. PMID: 19883264
32. Results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype. PMID: 19801679
33. Myocardin is a critical serum response factor cofactor regulating smooth muscle cell differentiation; forced expression of myocardin activated expression of SM22 alpha, smooth muscle alpha-actin, and calponin-h1 genes in mouse ES cells PMID: 12640126
34. HERP1 and myocardin expression was localized to smooth muscle cells in the neointima in human coronary atherosclerotic lesions. PMID: 16151017
35. myocardin-MYOCD overexpression in small cerebral arteries appears to initiate independently of amyloid beta-peptide a pathogenic pathway mediating arterial hypercontractility PMID: 17215356
36. Myocardin is frequently repressed during malignant transformation, contributing to a differentiation defect PMID: 17292825
37. the SRC3-myocardin interaction is a site of convergence for nuclear hormone receptor-mediated and VSMC-specific gene regulation PMID: 17360478
38. Data show that fibroblasts from human postmyocardial infarction scars acquire properties of cardiomyocytes after transduction with a recombinant myocardin gene. PMID: 17579192
39. Forced expression of the myocardin (MyoC) gene in human ventricular scar fibroblasts leads to MyoC-dependent activation of genes that encode connexins, strongly enforcing intercellular electrical coupling. PMID: 17938287
40. data suggest that functional natural myocardin promoter variation might be a genetic factor contributing to inter-individual differences in the development of cardiac hypertrophy PMID: 18028454
41. Myocd is sufficient for the establishment of a SMC-like contractile phenotype. PMID: 18451334
42. Foxo3a could negatively regulate myocardin expression levels through up-regulating catalase and the consequent reduction of ROS levels PMID: 18772130
43. A rare human sequence variant reveals myocardin autoinhibition PMID: 18852265
44. We suggest that SRF and MYOCD function as a transcriptional switch, controlling Abeta cerebrovascular clearance and progression of AD. PMID: 19098903
45. Results show that human retroperitoneal LMS differentiation is dependent on MYOCD amplification/overexpression, suggesting that in these well-differentiated LMS, differentiation could be a consequence of an acquired genomic alteration. PMID: 19276386
46. analysis of a novel mode of modulation of SM gene transcription by ERK1/2 through a direct phosphorylation of myocardin PMID: 19776005
47. MYOCD can discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter PMID: 19797053
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亞細胞定位：

Nucleus.
組織特異性：

Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle.
數據庫鏈接：

HGNC: 16067

OMIM: 606127

KEGG: hsa:93649

STRING: 9606.ENSP00000401678

UniGene: Hs.462257

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