MYH2 Antibody

中文名稱：

MYH2兔多克隆抗體
貨號：

CSB-PA892458LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate
All lanes: MYH2 antibody at 1:1250
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 224, 80 kDa
Observed band size: 224 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MYH2 Polyclonal antibody
Uniprot No.：

Q9UKX2
基因名：

MYH2
別名：

adult 2 antibody; Fast 2a myosin heavy chain antibody; IBM3 antibody; Inclusion body myopathy 3, autosomal dominant antibody; MYH2 antibody; MYH2_HUMAN antibody; MYH2A antibody; MYHas8 antibody; MyHC IIa antibody; MyHC-2a antibody; MyHC-IIa antibody; MYHSA2 antibody; Myosin heavy chain 2 antibody; Myosin heavy chain 2a antibody; Myosin heavy chain antibody; Myosin heavy chain IIa antibody; Myosin heavy chain skeletal muscle adult 2 antibody; Myosin heavy polypeptide 2 skeletal muscle adult antibody; Myosin-2 antibody; MYPOP antibody; skeletal muscle antibody; Type IIA myosin heavy chain antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Myosin-2 protein (1154-1300AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MYH2 Antibody (CSB-PA892458LA01HU)，的標記方式是Non-conjugated。對于MYH2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA892458LB01HU	MYH2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA892458LC01HU	MYH2 Antibody, FITC conjugated
Biotin	CSB-PA892458LD01HU	MYH2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Muscle contraction. Required for cytoskeleton organization.
基因功能參考文獻：
1. Exome analysis revealed homozygosity for a novel truncating mutation p.G800fs27* in the Myosin Heavy Chain 2 (MYH2) gene in both brothers, while parents and an unaffected sibling were heterozygous PMID: 28729039
2. differential regulation of PKA and cell stiffness in unconfined versus confined cells is abrogated by dual, but not individual, inhibition of Piezo1 and myosin II. PMID: 27160899
3. C-terminal Myosin IIA Heavy Chain phosphorylation sites are critical for recruitment of Myosin IIA to lamellar protrusions and for marginal paxillin phosphorylation during active cell spreading. PMID: 28053086
4. Data shoe that five of the patients were homozygous for myosin heavy chain 2 (MYH2) missense mutations, one patient was compound heterozygous for a missense and a nonsense mutation and one patient was homozygous for a frame-shift MYH2 mutation. PMID: 24193343
5. We have found that a greater MyH2 content in the vastus lateralis is accompanied by a higher oxygen cost of cycling during exercise performed below the lactate threshold. PMID: 24781731
6. This study presented more case in MYH2 mutation in recessive myopathy with external ophthalmoplegia linked to chromosome 17p13.1-p12. PMID: 23388406
7. A previously unrecognized interplay between actin and myosin IIA in podosomes, is demonstrated. PMID: 23361003
8. Myosin heavy chain 2A transcripts decreased significantly in skeletal muscle tissue from overnight parenterally fed patients but did not change significantly in orally refed mice PMID: 23190566
9. Phenotypic expression of alpha-smooth muscle actin, smooth muscle myosin heavy chain 2, and smoothelin were significantly decreased in the dissected media, whereas that of osteopontin was elevated. PMID: 22960022
10. This study demonistrated that the missense mutation c.2542T>C (p.V805A) in the MYHC2A gene. PMID: 22349865
11. The human genioglossus muscle is composed of conventional myosin heavy chain isoforms and 3 primary myosin hevy chain phenotypes. PMID: 22337492
12. NMMII and actin isoform expression changes coordinately with the remodeling phase of repair, and NMMII is increased as matrix stiffness increases. As NMMII expression increases, so does the fibroblast contractility. PMID: 21102503
13. Null mutations in the fast myosin heavy chain IIa gene cause early onset myopathy and demonstrate that this isoform is necessary for normal muscle development and function. PMID: 20418530
14. investigated the relation between expression of the mutant MyHC IIa and pathologic changes in muscle PMID: 11889243
15. Data suggest that changes in intracellular calcium may play a role in shifts in myosin heavy chain IIa (MyHC IIa) expression during muscle activation. PMID: 12235157
16. IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression in cell differentiation PMID: 15496418
17. analysis of normal variation indicates that there is strong selective pressure against mutations in MYH2; On the basis of these results, we suggest that MyHC genes should be regarded as candidate genes in hereditary myopathies of unknown etiology. PMID: 15741996
18. Our results provide evidence that the pathogenesis of the MyHC IIa E706K myopathy involves defective function of the mutated myosin as well as alterations in the structural integrity of all muscle cells irrespective of MyHC isoform expression. PMID: 17005402
19. myosin II has a role in glioma invasion of the brain PMID: 18495866
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相關疾病：

Myopathy, proximal, and ophthalmoplegia (MYPOP)
亞細胞定位：

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
數據庫鏈接：

HGNC: 7572

OMIM: 160740

KEGG: hsa:4620

STRING: 9606.ENSP00000245503

UniGene: Hs.667534

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