MYH14 Antibody

說明書

中文名稱：

MYH14兔多克隆抗體
貨號：

CSB-PA015293GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q7Z406
基因名：

MYH14
別名：

2400004E04Rik antibody; DFNA4 antibody; DKFZp667A1311 antibody; FLJ13881 antibody; FLJ43092 antibody; FP17425 antibody; II C antibody; KIAA2034 antibody; MHC16 antibody; Myh 14 antibody; MYH14 antibody; MYH14_HUMAN antibody; Myosin 14 antibody; Myosin antibody; Myosin heavy chain 14 antibody; Myosin heavy chain antibody; Myosin heavy chain non muscle IIc antibody; Myosin heavy polypeptide 14 antibody; Myosin-14 antibody; NMHC II C antibody; NMHC II-C antibody; Non muscle myosin heavy chain IIc antibody; non-muscle IIc antibody; Non-muscle myosin heavy chain IIc antibody; Nonmuscle myosin heavy chain II C antibody; OTTMUSP00000019210 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human MYH14
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
基因功能參考文獻：
1. This is the first identification of mutations in MYH14 as a cause of Anorectal malformations. PMID: 28191911
2. By reporting two novel variants of MYH14, we suggest that the present study extends the phenotypic spectrum of autosomal dominant MYH14 variants to include nonsyndromic, severe-to-profound hearing loss with prelingual onset. PMID: 28221712
3. phosphorylation of human cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice PMID: 26124132
4. The data show that although NM IIA and IIB form filaments with similar properties, NM IIC forms filaments that are less well suited to roles such as tension maintenance within the cell. PMID: 24072716
5. Results support the hypothesis that there is another DFNA gene upstream of the MYH14 gene and it may be linked to the DFNA4 locus. PMID: 23273769
6. the alterations of the MYH14 gene may contribute to Myotonic dystrophy type 1 molecular pathogenesis. PMID: 21872659
7. A complex phenotype of peripheral neuropathy, myopathy, hoarseness, and hearing loss is linked to an autosomal dominant mutation in MYH14 PMID: 21480433
8. kinetic and functional characterization of the motor domains of human nonmuscle myosin-2C isoforms PMID: 21478157
9. data identify CEACAM16 as an alpha-tectorin-interacting protein that concentrates at the point of attachment of the TM to the stereocilia and, when mutated, results in ADNSHL at the DFNA4 locus PMID: 21368133
10. Mutation in MYH14 gene can cause dominant non-syndromic hearing impairment in Asian population, suggesting that MYH14 gene can be a disease-causing gene of Chinese patients with hearing impairment. PMID: 20533261
11. mutational screening in a large series of 300 hearing-impaired patients from Italy, Spain, and Belgium and in a German kindred linked to DFNA4 PMID: 15015131
12. mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C PMID: 15845534
13. data do not support the involvement of MYH14 in cleft lip and palate among the Italian population PMID: 18471249
14. the alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation PMID: 19240025
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相關疾病：

Deafness, autosomal dominant, 4A (DFNA4A); Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH)
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
組織特異性：

High levels of expression are found in brain (highest in corpus callosum), heart, kidney, liver, lung, small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No
數(shù)據(jù)庫鏈接：

HGNC: 23212

OMIM: 600652

KEGG: hsa:79784

STRING: 9606.ENSP00000262269

UniGene: Hs.467142

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