MXI1 Antibody, Biotin conjugated
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中文名稱：MXI1兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA015254LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MXI1 Polyclonal antibody
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Uniprot No.：
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基因名：MXI1
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別名：bHLHc11 antibody; Class C basic helix-loop-helix protein 11 antibody; MAD 2 antibody; MAD2 antibody; MAX dimerization protein 2 antibody; MAX interacting protein 1 antibody; Max interactor 1 antibody; Max related transcription factor antibody; MAX-interacting protein 1 antibody; MGC43220 antibody; MXD 2 antibody; MXD2 antibody; MXI 1 antibody; MXI antibody; mxi1 antibody; MXI1 protein antibody; MXI1_HUMAN antibody; Protein MXI1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Max-interacting protein 1 protein (75-173AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
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基因功能參考文獻：
- Reactive oxygen species mediates hypoxia-induced VEGF by upregulation of Mxi1-0. PMID: 28065785
- results suggest that Mxi1-0 regulates the growth of HUVECs via the IL-8 and ERK1/2 pathways, which apparently reciprocally activate each other PMID: 28575053
- MYC-HEG and MXI1-LEG levels are associated with poor prognosis in patients with breast cancer, suggesting that they may be useful molecular markers in breast cancer prognosis prediction. PMID: 24685915
- MicroRNA-155 promotes glioma cell proliferation via the regulation of MXI1. PMID: 24376632
- MXI1-0 appears to be a downstream target of MYCN-dependent signaling pathways and may contribute to N-Myc-dependent cell growth and proliferation. PMID: 24403858
- These findings reveal, for the first time, the novel functions of cooperation of miR243p and miR27a3p from two clusters in promoting cell proliferation through MXI1. PMID: 23254855
- Mxi1 can act as a tumour suppressor in human glioblastomas through a molecular mechanism involving the transcriptional down-regulation of cyclin B1 gene expression. PMID: 11875718
- These findings support MXI1 as a putative tumor suppressor gene involved in conventional melanoma progression. PMID: 14559981
- Mxi1-SRalpha is an isoform with enhanced transcriptional repression potential PMID: 15467743
- Data show that PTEN and MXI1 were two candidate tumor suppressor genes on 10q23 and 10q24-q25 and may be potentially involved in the initiation and progression of prostate carcinoma. PMID: 15476185
- Mxi-D may play an important role in the c-Myc family protein network acting as a dominant negative isoform of Mxi-F stimulated by c-Myc PMID: 15809730
- p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1 PMID: 16126174
- MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma. PMID: 17102621
- These results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additional mechanism through which the PI3-kinase/Akt/FOXO pathway can modulate Myc function. PMID: 17452451
- Mad1, Mxi1 and Rox genes were expressed and displayed mutations in haematological malignancies. PMID: 17577784
- Mxi1 gains functional complexity by encoding isoforms with shared and distinct activities PMID: 17697116
- Missense mutations in Mad1, Mxi1 and Rox were found in acute leukemia patients. PMID: 18457265
- Mxi1 is an important downstream target of HIF that contributes to pVHL-deficient renal cancer tumorigenesis PMID: 19018165
- MAX interactor-1 (MXI1) gene is directly regulated by HIF-1alpha protein in neuroblastoma and breast cancer cells. PMID: 19254710
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相關疾?。?/div>Prostate cancer (PC)亞細胞定位：Nucleus.組織特異性：High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.數據庫鏈接：
