MXD1 Antibody
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中文名稱：MXD1兔多克隆抗體
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貨號：CSB-PA015251GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MXD1
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別名：MAD antibody; MAD protein antibody; MAD1 antibody; MAD1_HUMAN antibody; MAX dimerization protein 1 antibody; Max dimerizer 1 antibody; Mxd1 antibody; Protein MAD antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MXD1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of a transcriptional repressor complex together with MAX. In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing with MYC for MAX binding. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
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基因功能參考文獻：
- Results suggest a role for MAX dimerization protein 1 (MXD1) in the control of ribosome biogenesis. PMID: 27588501
- Study revealed that HIF-1alpha-induced Mxd1 contributes to cisplatin-resistance in hypoxic osteosarcoma cells by directly repressing PTEN, which leads to the activation of PI3K/AKT antiapoptotic and survival pathway. PMID: 28543796
- the miR-382-5p/MXD1 axis plays a critical role in myelopoiesis by affecting the lineage choice of CD34(+) hematopoietic stem/progenitor cells. PMID: 27520398
- TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression. PMID: 26698869
- down regulation of miR-202 increased the expression of its target Mxd1, followed by Mxd1 recruitment to the Sin3A repressor complex and through its dimerization with Max, and increased repression of Myc-Max target proteins. PMID: 25611699
- miR-17-92 cluster members miR-19a/b facilitated gastric cancer cell migration, invasion and metastasis through targeting the antagonist of c-Myc -- MXD1. PMID: 24675462
- This study suggests that genetic variants of MXD1 may modulate the effect of smoking on carotid plaque burden. PMID: 24954085
- Mad1 gene transfer inhibits the proliferation of human melanoma cells PMID: 12366697
- HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations PMID: 15235594
- MAD1 and Proto-Oncogene Proteins c-myc reciprocally regulate ribosomal DNA transcription, providing a mechanism for coordination of ribosome biogenesis and cell growth PMID: 15282543
- c-myc and mad1 can regulate the hTERT transcript in a different manner in hTERT positive cells, but not in normal cells PMID: 15645079
- Mad1, Mxi1 and Rox genes were expressed and displayed mutations in haematological malignancies. PMID: 17577784
- This study provides a direct link between the growth factor signaling pathways regulated by PI3 kinase/Akt and MAP kinases with Myc-mediated transcription. PMID: 18451027
- TGF-beta can override Myc activity despite a stabilizing cancer mutation and induce senescence in myeloid tumor cells, at least in part by induction of Mad1 PMID: 19766114
- examination of functionality of basic domains compared with Myc PMID: 12538578
- X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. PMID: 12553908
- Mad expression and Id2 down-regulation are important events during the TGF-beta cytostatic program in epithelial cells. PMID: 12824180
- Max as a novel co-activator of C/EBPalpha functions, thereby suggesting a possible link between C/EBPalpha and Myc-Max-Mad network. PMID: 17082780
- The PTEN tumor suppressor gene is a target of MAD1. PMID: 17998413
- Mxd1 D112a and Max N78a and H81d, which are located in the leucine zippers of the proteins, can dictate the specificity of heterodimerization and whether or not the Mxd1/Max/DNA complex forms. PMID: 18155722
- Results suggest STAT3 functions as a C/EBPbeta cofactor in the regulation of the MAD1 gene. PMID: 18203738
- Missense mutations in Mad1, Mxi1 and Rox were found in acute leukemia patients. PMID: 18457265
- results suggest that phosphorylation of MAD1 by AKT inhibits MAD1-mediated transcription suppression and subsequently activates the transcription of MAD1 target genes PMID: 19526459
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亞細胞定位：Nucleus.
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