MX1 Antibody, Biotin conjugated
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中文名稱：MX1兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA015249LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MX1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Human interferon regulated resistance GTP binding protein MXA antibody; IFI 78 antibody; IFI 78K antibody; IFI-78K antibody; IFI78 antibody; IFI78K antibody; Interferon induced GTP binding protein Mx1 antibody; Interferon induced protein p78 antibody; Interferon inducible protein p78 antibody; Interferon regulated resistance GTP binding protein antibody; Interferon regulated resistance GTP binding protein MxA antibody; Interferon-induced GTP-binding protein Mx1 antibody; Interferon-induced protein p78 antibody; Interferon-regulated resistance GTP-binding protein MxA antibody; MX 1 antibody; MX antibody; MX dynamin-like GTPase 1 antibody; MX1 antibody; MX1_HUMAN antibody; MxA antibody; Myxoma resistance protein 1 antibody; Myxovirus (influenza virus) resistance 1 interferon inducible antibody; Myxovirus (influenza virus) resistance 1 interferon inducible protein p78 antibody; Myxovirus (influenza) resistance 1 homolog of murine antibody; Myxovirus resistance 1; mouse; homolog of antibody; Myxovirus resistance protein 1 antibody; N-terminally processed antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Interferon-induced GTP-binding protein Mx1 protein (7-172AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
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基因功能參考文獻：
- MxA conformational dynamics through GTP hydrolysis revealed by single-molecule fluorescence resonance energy transfer. PMID: 28548099
- IL28B and MxA gene genotypes were detected among 231 chronic hepatitis C (CHC) carriers, 428 subjects with hepatitis C virus spontaneous clearance and 662 CHC patients with pegylated IFN-alpha and ribavirin (pegIFN-alpha/RBV) treatment. PMID: 29271328
- Mx1 and OAS1-2 polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis. PMID: 28139728
- MxA inhibits hepatitis C virus replication through JAK-STAT pathway activation. PMID: 29417241
- findings indicated that MxA over-expression inhibited HCV replication and potentiated the IFNalpha-mediated anti-HCV activity; MxA stimulated the production of IFNalpha, IFNbeta, and enhanced IFNalpha-induced activation of Jak-STAT signaling pathway; concluded that MxA is a positive regulator of type I IFN signaling in HCV infection PMID: 28561372
- Relative expression of OAS1 and Mx1 in patients with recurrent forms of Herpes simplex both during the acute stage and clinical remission did not differ significantly from that in healthy people after stimulation with IFN-alpha2b. PMID: 28744639
- Study demonstrated associations between rs464138 AA genotype in MxA gene and IFNbeta responsiveness in multiple sclerosis patients. However, the allele and genotype frequencies of other SNPs were not significantly different among patient subtypes or between patients and controls. Besides, results demonstrated that CGC, ATA, and AGA (-123, -88, +20) haplotypes were significantly associated with IFNbeta response in MS pa... PMID: 28386647
- High expression of MxA in tumor cells was associated with high levels of TILs in HER2-positive breast cancers. Additionally, a high level of TILs was a prognostic factor for breast cancer, whereas the level of MxA expression had no prognostic value. PMID: 27456948
- studied the susceptibility of Vaccinia virus and Cowpox viruses to MxA antiviral action, and concluded that these viruses are not affected by the antiviral action of MxA PMID: 28727764
- Here, the authors show that for North African patients with chronic hepatitis, MX1 gene variation at position -123 may influence the outcome of hepatitis B virus infection but not hepatitis B virus infection. PMID: 27458866
- the data identify MxA as a novel stimulator of BMP4 and BMP9 transcriptional signaling, and suggest it to be a candidate IFN-alpha-inducible mechanism that might have a protective role against development of pulmonary arterial hypertension and other vascular diseases. PMID: 27875556
- This study provides Class II evidence that immunohistochemistry-detected sarcoplasmic MxA expression accurately identifies patients with dermatomyositis (DM): sarcoplasmic MxA expression detected by immunohistochemistry is a more sensitive marker of DM than the conventional hallmarks PMID: 28039312
- A significant association was observed between MX1 -88G/T SNP and susceptibility to systemic lupus erythematosus PMID: 26815367
- Study shows different levels of expression of MxA in each breast cancer subtype and its close relationship with tumor-infiltrating lymphocytes. MxA protein expression was higher in triple-negative breast cancer and correlated with a higher histologic grade. PMID: 27075916
- This study demonstrated that MxA mRNA expression of interferon beta response in multiple sclerosis patients. PMID: 26857498
- Transient dimerization of human MxA promotes GTP hydrolysis.The GTPase domains of Mx proteins dimerize transiently to facilitate catalysis. PMID: 25295396
- polymorphism at position -88 in the MxA promoter region might be a potential biomarker to predict HCV progression toward end-stage fibrosis and response to IFN-based therapy in chronic hepatitis C patients. PMID: 25868067
- data suggest that, during infection, a fraction of MxA disassembles into dimers that bind to NP synthesized following primary transcription in the cytoplasm, thereby preventing viral replication PMID: 26507657
- heterozygosity for both -88G/T and -123C/A polymorphisms of the MxA gene is important host factor that influence the response to IFN therapy in patients with chronic HCV infection. PMID: 25239021
- E2F1 transcripts and miR-17-5p were significantly downregulated while c-Myc and MxA transcripts were significantly upregulated in SLE. PMID: 26175399
- Baseline MxA mRNA levels may be useful for predicting whether multiple sclerosis patients will respond or not to interferon-beta treatment. PMID: 25396411
- upregulated in the skin of Lichen planus patients PMID: 25384438
- Blood MxA protein levels are increased in young children with symptomatic respiratory virus infections, including rhinovirus infections. MxA is an informative general marker for the most common acute virus infections. PMID: 25542463
- Reovirus T3D infection induced STAT-1, ISG-15, IFIT-1, Mx1, and IFIT-3 expression. PMID: 25905045
- study highlights the role of nucleotide binding and hydrolysis for the intracellular dynamics of MxA during its antiviral action. PMID: 25829498
- These data warrant the quantification of MxA mRNA as a primary tool for a routine monitoring of IFNbeta therapy. PMID: 24733382
- MxA expression is inversely correlated with prostate cancer. Down-regulation of MxA in LNCaP cells by DHT suggests that MxA could play a significant role in disease progression. PMID: 25327819
- MxA interacts with Ubc9 and SUMO1 in a yeast two-hybrid system. PMID: 25447205
- These studies disclosed that antiviral IFN-induced MxA and APOBEC3G/3F mRNA levels were increased after IL-32gamma treatment of peripheral blood mononuclear cells. PMID: 24553842
- Plasmacytoid dendritic cells in the infiltrate of progressive vitiligo produce MxA. Strong MxA expression was seen in perilesional skin near remaining melanocytes, surrounded by a prominent T-cell infiltrate, but it was not detectable in lesional skin. PMID: 24438589
- MX1 may have a role in lymph node metastasis in colorectal carcinoma PMID: 24771638
- It describes the standardized cellular myxovirus resistance protein A (MxA) protein measurement-based assay for detection of IFN-beta NAbs and its use for the validation of assays used for the quantitative determination of such antibodies. PMID: 23848523
- antiviral innate immunity may be involved in mesangial cells (MCs) of lupus nephritis patients, which results in the expression of Mx1 in MCs. PMID: 24674141
- Varicella-zoster virus inhibits the nuclear translocation of phosphorylated-STAT1 and antiviral MX1 protein expression in human brain vascular adventitial fibroblasts. PMID: 25056900
- Upregulation of MxA expression during the early stages of Graves disease, and the correlation between the number of PDCs and MxA+ leucocytes, suggests that activated PDCs secrete type I IFNs at the lesion site, possibly in response to viral infection. PMID: 24032645
- protein expression is inhibited by hepatitis C virus PMID: 23529855
- The L4 loop of the stalk domain of MX1 is a critical determinant. PMID: 24899177
- MxA protein levels in whole blood and monocytes correlated with primary Sjogren's syndrome disease activity and IFN type I bioactivity. PMID: 23831963
- Hepatitis C genotype 1 patients who were responders to interferon-based therapy had a high frequency of multiple protective polymorphisms in the myxovirus resistance protein, osteopontin and suppressor of cytokine signaling 3 genes. PMID: 24212839
- Data indicate susceptibility genes including myxovirus (influenza virus) resistance 1 (MX1) for respiratory syncytial virus (RSV) disease severity and risk. PMID: 24421397
- polymorphisms in the MxA promoter may play a role in mediating the susceptibility to enterovirus 71 infection in Chinese population PMID: 24085612
- Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virus. PMID: 24448803
- Studied the association of the functional polymorphism rs2071430 in MxA with prostate cancer.A significant association was observed between rs2071430 genotype GG and prostate cancer. Individuals with the GG genotype have increased risk of prostate cancer. PMID: 23438650
- these results show that allelic diversity in the MxA gene proximal promoter significantly alter the tight regulation of antiviral MxA protein expression by type-I and type-III interferons. PMID: 22985419
- MxA protein sequestered the West Nile virus capsid protein in cytoplasmic tubular structures and resulted in reduced titers of secreted virus particles. PMID: 24314641
- Interferon-induced MxA protein inhibits influenza A virus infection by retaining the incoming viral genome in the cytoplasm. PMID: 24049170
- myxovirus resistance protein A expression is increased in thyroid tissue in the early stages of Hashimoto's thyroiditis PMID: 22998463
- IL-17A but not IL-22 suppresses the replication of hepatitis B virus by inducing the expression of MxA and OAS. PMID: 23274784
- This is the first study showing the significant association of MxA SNPs and predisposition of AD, modulation of AAO in AD, and rate of cognitive decline. PMID: 22950423
- The MxA-88T/-123A gene variants indirectly increase the risk for heptaitis C virus infection. PMID: 23232524
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亞細胞定位：Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region.; [Isoform 2]: Cytoplasm. Nucleus.
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蛋白家族：TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
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