MTAP Antibody

中文名稱：

MTAP兔多克隆抗體
貨號：

CSB-PA622639LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate, Mouse liver tissue, Mouse kidney tissue
All lanes: MTAP antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 32, 39, 37, 31, 34, 33, 27 kDa
Observed band size: 32, 39 kDa

Immunofluorescent analysis of U251 cells using CSB-PA622639LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MTAP Polyclonal antibody
Uniprot No.：

Q13126
基因名：

MTAP
別名：

5' methylthioadenosine phosphorylase antibody; 5''-methylthioadenosine phosphorylase antibody; BDMF antibody; c86fus antibody; DMSFH antibody; DMSMFH antibody; Epididymis luminal protein 249 antibody; HEL 249 antibody; LGMBF antibody; MeSAdo phosphorylase antibody; Methylthioadenosine phosphorylase antibody; MSAP antibody; MTA phosphorylase antibody; MTAP antibody; MTAP_HUMAN antibody; MTAPase antibody; S methyl 5 thioadenosine phosphorylase antibody; S methyl 5' thioadenosine phosphorylase antibody; S-methyl-5''-thioadenosine phosphorylase antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human S-methyl-5\'-thioadenosine phosphorylase protein (1-283AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MTAP Antibody (CSB-PA622639LA01HU)，的標記方式是Non-conjugated。對于MTAP Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA622639LB01HU	MTAP Antibody, HRP conjugated	ELISA
FITC	CSB-PA622639LC01HU	MTAP Antibody, FITC conjugated
Biotin	CSB-PA622639LD01HU	MTAP Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:2000-1:10000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
基因功能參考文獻：
1. melanoma risk alleles correlate with an allele-specific hyper-methylation and down-regulation of gene expression PMID: 27761950
2. The obtained data suggested a negative association between copy number variation of the MEAP genes and Atherothrombotic stroke. PMID: 28477716
3. High MTAP expression is associated with prostate cancer. PMID: 26910893
4. Results indicate complex rearrangements involving CDKN2A locus and frequent occurrence of fusion transcripts involving methylthioadenosine phosphorylase (MTAP) and ANRIL genes. PMID: 26909863
5. The SNP rs7023954 of methylthioadenosine phosphorylase co-dominantly expressed alleles revealed no difference in the conversion rate of 5'-methylthioadenosine to adenine and 5-methylthioribose-1-phosphate, indicating that this known enzymatic activity does not modulate the tumor suppressive function of methylthioadenosine phosphorylase. PMID: 27479139
6. Data demonstrate that MTAP deficiency leads to accumulation of MTA inducing deregulation of central cellular pathways that control cell fate and contributes to the onset of a proliferative and antiapoptotic phenotype in the liver. PMID: 26819315
7. methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion. PMID: 27068473
8. MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors. PMID: 26751376
9. study to describe MTAP expression in a series of Pilocytic astrocytomas and relate it to the clinicopathological features of the patients; found MTAP expression is retained in Pilocytic astrocytomas and is not an outcome predictor for these tumors PMID: 26088413
10. MTAP deficiency was predictive of worse disease-specific survival and distant metastasis-free survival, suggesting its role in disease progression and as an independent prognostic biomarker of nasopharyngeal carcinoma PMID: 26656376
11. In the MTAP-deficient cases, the homozygous deletion of MTAP predicted adverse outcome. In MTAP-deficient cells, MTAP reexpression inhibited cell migration and invasion, proliferation and anchorage-independent colony formation and downregulated cyclin D1. PMID: 25426549
12. MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients. PMID: 24969958
13. MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB activation and apoptosis in hepatic stellate cells. PMID: 24324622
14. SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD. PMID: 23462334
15. Homozygous deletion of MTAP gene is associated with haploid lymphoblastic leukemia. PMID: 23508829
16. Authors report here that a high percentage of t-cell lymphoma lack the enzyme methylthioadenosine phosphorylase (MTAP). PMID: 23040436
17. MTAP gene might be involved in the etiology of myocardial infarction in Chinese Han ethnicity. PMID: 20302706
18. Letter: inactivation of MTAP expression seems to be an important step in the development and progression of malignant melanoma. of PMID: 23000879
19. Data indicate that a signature of seven biomarkers (Bax, Bcl-X, PTEN, COX-2, beta-Catenin, MTAP and CD20) was found to be an independent negative predictor for overall and recurrence-free survival in cutaneous malignant melanoma (MM). PMID: 22685558
20. A large negative heat capacity change of -600 cal/(mol K) upon inhibitor binding to MTAP is consistent with altered hydrophobic interactions and release of water. PMID: 21985704
21. Polymorphisms in nevus-associated genes MTAP is associated with invasive cutaneous melanoma. PMID: 21962134
22. The present study suggests that MTAP plays an important role in the regulation of gastric carcinogenesis. PMID: 21412930
23. Expression of MTAP is significantly higher in human colorectal cancer than in normal colorectal tissues. Demethylation of MTAP promoter may play an important role in up-regulating MTAP expression. PMID: 19622299
24. The expression of MTAP protein in non-small cell lung cancer tissue was significantly lower than that in paracarcinomous tissue and borderline lung tissue. PMID: 21342647
25. MTAP deficiency results in accumulation of 5'-deoxy-5'-methylthioadenosine, which is associated with increased tumorigenicity. PMID: 21356366
26. CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)), and MTAP are abundantly expressed in atherosclerotic lesions. PMID: 20637465
27. MTDIA antitumor activity in xenografts supports MTAP as a target for lung cancer therapy. PMID: 21135097
28. Single nucleotide polymorphism in MTAP gene is associated with nevi. PMID: 20574843
29. Detection of CDKN2A-MTAP co-deletion in peritoneal mesotheliomas can help identify those patients who may have an unfavorable outcome PMID: 20081810
30. MTAP homozygous deletion, the predominant mechanism to deplete protein expression, is present in 17% of gastrointestinal stromal tumors PMID: 19887491
31. Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line. PMID: 12438261
32. Results suggest an important role of methylthioadenosine phosphorylase inactivation in the development of melanomas. PMID: 12875987
33. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites PMID: 14506228
34. MTAP is not expressed in normal human colonic epithelium but is strongly upregulated in colon carcinoma. PMID: 15492751
35. epigenetic mechanisms, involving DNA methylation and histone deacetylation, may play a role in the silencing of MTAP gene expression in hepatocarcinoma PMID: 15511635
36. MTAP activity is frequently lost, and ODC activity is frequently elevated in both pancreatic adenocarcinoma and neuroendocrine tumors PMID: 15534104
37. MTAP expression is lost in approximately 30% of infiltrating pancreatic cancers and in a lower percentage of other periampullary neoplasms; loss is a result of homozygous deletions encompassing both the MTAP and p16INK4A/CDKN2A genes PMID: 15662124
38. Results demonstrated concordant loss of MTAP and p16 protein expression in pancreatic intraepithelial neoplasia. PMID: 15832197
39. MTAP inactivation is associated with hepatocellular carcinoma development and invasiveness PMID: 16081515
40. Selective loss at the 3' end of MTAP was observed in head and neck squamous cell carcinoma cell line UMSCC-11A. PMID: 16618910
41. The frequency of Methylthioadenosine phosphorylase (MTAP) deletions in conventional, grade II chondrosarcomas by fluorescence in situ hybridization (FISH) analysis was investigated. PMID: 16631464
42. Methylthioadenosine phosphorylase (MTAP) gene deletion and lack of protein expression are associated with poor prognosis in mantle cell lymphoma. PMID: 16778103
43. Regulation of MTAP by reactive oxygen species might participate in the redox regulation of the methionine catabolic pathway in the liver PMID: 18237276
44. analysis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma PMID: 18555557
45. This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of myocardial infarction in Chinese. PMID: 19272367
46. The G allele of rs10118757 was associated with an increased risk of stroke in Han Chinese even after controlling for confounding factors. The GA+GG genotype was associated with the increased risk of an undetermined subtype of ischemic stroke. PMID: 19427650
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相關疾病：

Diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH)
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

PNP/MTAP phosphorylase family, MTAP subfamily
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 7413

OMIM: 112250

KEGG: hsa:4507

STRING: 9606.ENSP00000369519

UniGene: Hs.193268

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