MSX2 Antibody
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中文名稱：MSX2兔多克隆抗體
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貨號：CSB-PA030362
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規(guī)格：￥2024
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圖片：
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Western blot analysis of extracts from COLO205 cells, using MSX2 antibody.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) MSX2 Polyclonal antibody
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Uniprot No.：
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基因名：MSX2
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthesized peptide derived from Internal of Human MSX2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
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基因功能參考文獻：
- MSX2 might be a new drug resistance related gene in pancreatic cancer cells by up-regulation of MRP2 expression. PMID: 29860758
- MSX2 played a crucial role in the progression of colorectal cancer and may be a potential novel prognostic factor PMID: 28286778
- MSX2 protein expression is downregulated in placental villi from Pre-Eclampsia. PMID: 27088357
- The MSX2 destabilizes the pluripotency circuitry through direct binding to the SOX2 promoter, while MSX2 controls mesendoderm lineage commitment by simultaneous suppression of SOX2 and induction of NODAL expression. PMID: 26427715
- This is the first report of an eye development defect due to an increase in the MSX2 copy number in a human being. PMID: 24666290
- SLUG and MSX2, transcription factors involved in epithelial-mesenchymal transitions, essential features of gastrulation in development and tumor progression, are important mediators of BMP4-induced differentiation in human embryonic stem cells. PMID: 24549638
- These data confirm that missense mutations altering the proline at codon 148 of MSX2 cause dominantly inherited craniosynostosis. PMID: 23949913
- PKC signaling modulates osteoblast differentiation, at least in part, through the regulation of Msx2. PMID: 22633971
- Msx2 and topo II-alpha may play an important role in the occurrence and development of sinonasal inverted papilloma. PMID: 22730815
- The pathogenic effect of the microduplications can best be explained by a misregulation of spatiotemporal MSX2 expression patterns in cleidocranial dysplasia. PMID: 22717651
- Cyclic tensile stress may induce differentiation of periodontal ligament stem cells towards mineralized tissue cells by promoting Dlx5 mRNA expression and decreasing Msx2 expression. PMID: 22332551
- The detailed regulatory mechanism of ABCG2 expression by MSX2 in pancreatic cancer cells was investigated. PMID: 21465479
- activation of RAGE not only inhibits myocardin-dependent SMC gene expression, but also induces osteogenic differentiation of vascular SMC through Notch/Msx2 induction PMID: 21512281
- findings indicate MSX2 is a direct downstream transcriptional target of beta-catenin/TCF and has a key contributing role in the cancer phenotype of OEAs carrying WNT/beta-catenin pathway defects PMID: 21499300
- MSX2 may be an important regulator of melanoma cell invasion and survival. Cytoplasmic expression of the protein was identified as biomarker for good prognosis in malignant melanoma. PMID: 21730974
- Notch1 intracellular domain.RBPJk complex enhances the BMP2-induced Msx2 gene expression by cooperating with Smad1 and suggest that Notch signaling makes vascular SMC responsive to BMP2 and promotes vascular calcification. PMID: 21471203
- Maternal Msx2 C386T gene polymorphisms were associated with fetal neural tube defects in Han Chinese women in Shanxi Province. PMID: 21362336
- The sensitivity of MSX2 expression level for cholangiocarcinoma was much higher than that of cytology. PMID: 21498730
- Data suggest that increased Msx2 expression results in improved outcome for breast cancer patients, possibly by increasing the likelihood of tumour cell death by apoptosis. PMID: 20682066
- Data reveal a selective upregulation of MSX2 expression in human fetal ovary in response to BMP4, suggesting this gene may act as a downstream effector of BMP-induced apoptosis in the ovary. PMID: 20506112
- MSX2 plays a pivotal role in the development of intraductal papillary mucinous neoplasm (IPMN) through growth stimulation of tumor cells, and its expression was identified as an independent predictive factor for malignancy of benign branch duct-IPMN PMID: 20107842
- TNF-alpha directly induces MSX2 expression through the NF-kappaB pathway, which in turn induces expression of alkaline phosphatase, a key molecule in mineralization, in VSMCs. PMID: 20004646
- MSX2 activates NOTCH3-signaling in leukemic T-cells. PMID: 19835636
- Bone sialoprotein expression is additionally regulated by the homeodomain factor Msx2, another regulator of osteoblast-associated genes. PMID: 12750290
- Results suggest that Msx2 plays a central role in preventing ligaments and tendons from mineralizing, in part by suppressing Runx2/Osf2 transcriptional activity. PMID: 15060165
- Results suggest that MSX2 exerts repressive effects on the gemcitabine-induced apoptotic pathway in pancreatic cancer cells. PMID: 16425399
- In dental follicle cells, gene expression of runx2, DLX-5, and MSX-2 was unaffected during osteogenic differentiation in vitro. PMID: 16467978
- This provides genetic evidence that Twist1, Msx2 and Efna4 function together in boundary formation and the pathogenesis of coronal synostosis. PMID: 16540516
- MSX2 homeobox mutation in a family with foramina parietalia permagna, headache, and vascular anomaly. PMID: 16642368
- vascular Bmp Msx2 Wnt signaling and oxidative stress have roles in arterial calcification [review] PMID: 18056036
- Msx2 expression may represent a useful prognostic marker in inverted papilloma. PMID: 18187185
- MSX2 polymorphisms are associated with ankylosing spondylitis in Japanese but not in Taiwanese population. PMID: 18299954
- These data indicate that MSX2 plays a crucial role in pancreatic cancer development by inducing changes consistent with epithelial to mesenchymal transition through enhanced expression of Twist 1. PMID: 18349132
- the primary function of MSX2 in suture closure is the induction of cell proliferation and suture maintenance, and the mutation results in an increased susceptibility of both wild type and mutant MSX2 to proteasomal degradation PMID: 18786927
- In this review, Msx2 is shown to function as a transcriptional enhancer downstream of fibroblast growth factor 2 in calvarial pre-osteoblastic cells. PMID: 19147956
- These results imply a new mechanism for osteogenic differentiation of vascular smooth muscle cellss in which Notch/RBP-Jk signaling directly induces Msx2(msh homeobox 2) gene expression . PMID: 19407244
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相關(guān)疾病：Parietal foramina 1 (PFM1); Parietal foramina with cleidocranial dysplasia (PFMCCD); Craniosynostosis 2 (CRS2)
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亞細胞定位：Nucleus.
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蛋白家族：Msh homeobox family
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