MSRB1 Antibody, HRP conjugated

說明書

中文名稱：

MSRB1兔多克隆抗體, HRP偶聯
貨號：

CSB-PA882163LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MSRB1 Polyclonal antibody
Uniprot No.：

Q9NZV6
基因名：

MSRB1
別名：

Annexin A2 like antibody; EC 1 8 4 antibody; HSPC 270 antibody; HSPC270 antibody; Methionine R sulfoxide reductase antibody; Methionine R sulfoxide reductase B1 antibody; Methionine sulfoxide reductase antibody; Methionine-R-sulfoxide reductase B1 antibody; MGC3344 antibody; MSRB 1 antibody; MsrB1 antibody; MSRB1_HUMAN antibody; OTTHUMP00000159418 antibody; Sel X antibody; Selenoprotein R antibody; Selenoprotein X 1 antibody; Selenoprotein X antibody; Selenoprotein X1 antibody; SELR antibody; SelX antibody; SEPX 1 antibody; sepx1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Methionine-R-sulfoxide reductase B1 protein (1-116AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
基因功能參考文獻：
1. In vivo, MsrB1 shRNAi can inhibit lung metastasis in metastasis model. In conclusion, MsrB1 regulates proliferation and invasion of u2os cells by affecting MAPK pathway and EMT, and MsrB1 gene may be a novel therapeutic target against tumors. PMID: 29395081
2. FRET and co-IP assays demonstrated that Clu interacted with beta-amyloid peptide, a pathological protein of AD, which suggested a potential effect of SelR and Abeta with the aid of Clu. The interaction between SelR and Clu provides a novel avenue for further study on the mechanism of SelR in AD prevention. PMID: 23805218
3. MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption. PMID: 24342607
4. findings suggested that SelX played important roles in protecting LO2 cells against oxidative damage and reducing H2O2-induced apoptosis in liver cells. PMID: 26899321
5. Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress PMID: 26875981
6. Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress. PMID: 23988788
7. MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption PMID: 24342607
8. MsrB1 plays important roles in protecting HLE cell mitochondria against oxidative damage and inhibits oxidative stress-induced apoptosis in diabetic cataracts by scavenging ROS. PMID: 23270945
9. The results demonstrate that in human lens epithelial cells MsrB1 may play important roles in regulating redox balance and mitigating endoplasmic reticulum stress. PMID: 22713178
10. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 21048031
11. The neutrophils expressed the highest activity Msrs. Msrs are important as antioxidant/repair systems for neutrophils, cells with enormous capacity for the generation of reactive oxidants and hence, susceptible to oxidative damage. PMID: 17938273
12. Strong candidate gene for schizophrenia; upregulated in lymphoblastoid cells of monozygotic twins. PMID: 18081029
13. The studies in mouse show that MsrB is a selenoprotein that exhibits high specificity for reduction of the R forms of free and protein-bound methionine sulfoxide. PMID: 11779133
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亞細胞定位：

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.
蛋白家族：

MsrB Met sulfoxide reductase family
數據庫鏈接：

HGNC: 14133

OMIM: 606216

KEGG: hsa:51734

STRING: 9606.ENSP00000355084

UniGene: Hs.655346

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