MRPL41 Antibody, FITC conjugated
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中文名稱：MRPL41兔多克隆抗體, FITC偶聯
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貨號：CSB-PA811620LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MRPL41 Polyclonal antibody
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Uniprot No.：
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基因名：MRPL41
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別名：39S ribosomal protein L27 homolog antibody; 39S ribosomal protein L41 antibody; 39S ribosomal protein L41 mitochondrial antibody; Bcl-2-interacting mitochondrial ribosomal protein L41 antibody; BMRP antibody; Cell proliferation-inducing gene 3 protein antibody; L41mt antibody; mitochondrial antibody; Mitochondrial ribosomal protein L41 antibody; MRP L27 antibody; MRP-L27 homolog antibody; MRP-L41 antibody; MRPL27 antibody; mRpL41 antibody; PIG3 antibody; Proliferation inducing gene 3 antibody; RM41_HUMAN antibody; RPML27 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human 39S ribosomal protein L41, mitochondrial protein (14-137AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
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基因功能參考文獻：
- Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. PMID: 24160266
- Apoptosis-inducing ability of wild-type BMRP is blocked by Bcl-2 through several mechanisms. PMID: 22711503
- region of BMRP required for the interaction with Bcl-2 is very relevant for the cell death-inducing activity of the protein PMID: 21253851
- BMRP is a mitochondrial ribosomal protein involved in the regulation of cell death by apoptosis, probably affecting pathways mediated by Bcl-2 and caspases. PMID: 15547950
- mitochondrial ribosomal protein L41 (MRPL41) is localized in the mitochondria, stabilizes the p53 protein, and enhances its translocation to the mitochondria, thereby inducing apoptosis. PMID: 16024796
- Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and p27(Kip1) levels under the growth inhibitory conditions. PMID: 16256947
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亞細胞定位：Mitochondrion.
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蛋白家族：Mitochondrion-specific ribosomal protein mL41 family
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組織特異性：Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
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數據庫鏈接：
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