MPEG1 Antibody, Biotin conjugated
產(chǎn)品詳情
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產(chǎn)品名稱：
Rabbit anti-Homo sapiens (Human) MPEG1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：
macrophage expressed 1 antibody; Macrophage expressed gene 1 antibody; Macrophage gene 1 protein antibody; Macrophage specific gene 1 antibody; Macrophage-expressed gene 1 protein antibody; Mpeg1 antibody; MPEG1_HUMAN antibody; Mpg-1 antibody; Mpg1 antibody; MPS1 antibody; MSG antibody
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宿主：
Rabbit
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反應(yīng)種屬：
Human
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免疫原：
Recombinant Human Macrophage-expressed gene 1 protein (537-633AA)
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免疫原種屬：
Homo sapiens (Human)
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標(biāo)記方式：
Biotin
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克隆類型：
Polyclonal
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抗體亞型：
IgG
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純化方式：
>95%, Protein G purified
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濃度：
It differs from different batches. Please contact us to confirm it.
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保存緩沖液：
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
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產(chǎn)品提供形式：
Liquid
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應(yīng)用范圍：
ELISA
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Protocols：
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儲(chǔ)存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點(diǎn)詳情
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功能：
Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores. By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence. Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide.
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基因功能參考文獻(xiàn)：
- these data provide the evidence that membrane-bound and secretory isoforms of perforin-2 are present in human macrophages and may play important roles in immune defense PMID: 28705375
- Collectively, these studies further underscore the biological significance of Perforin-2 and elucidate critical molecular events that culminate in Perforin-2-dependent killing of both intracellular and extracellular, cell-adherent bacteria. PMID: 26418746
- the impact of Perforin-2/macrophage-expressed protein 1 from the earliest multicellular organisms to modern vertebrates, as well as review the development of other membrane attack complexes of complement and Perforin domain member proteins PMID: 26307549
- Knockdown of perforin-2 in macrophages did not alter the invasion of host cells but did result in chlamydial growth that closely mirrored that detected in HeLa cells. PMID: 23753625
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亞細(xì)胞定位：
[Isoform 1]: Cytoplasmic vesicle membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
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組織特異性：
Expressed constitutively in a variety of cell types including macrophages, natural killer cells, neutrophils, keratinocytes and monocytes. In skin, expressed in both hematopoietic and non-hematopoietic cells with expression detected in a variety of cell t
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