MNAT1 Antibody

中文名稱：

MNAT1兔多克隆抗體
貨號：

CSB-PA014686LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Mouse brain tissue
All lanes: MNAT1 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 36, 32 kDa
Observed band size: 36 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA014686LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MNAT1 Polyclonal antibody
Uniprot No.：

P51948
基因名：

MNAT1
別名：

MNAT 1 antibody; CAP35 antibody; CDK activating kinase assembly factor MAT1 antibody; CDK-activating kinase assembly factor MAT1 antibody; CDK7/cyclin H assembly factor antibody; CDK7/cyclin-H assembly factor antibody; Cyclin G1 interacting protein antibody; Cyclin-G1-interacting protein antibody; MAT1 antibody; MAT1_HUMAN antibody; Menage a trois 1 (CAK assembly factor) antibody; Menage a trois antibody; Menage a trois homolog 1; cyclin H assembly factor (Xenopus laevis) antibody; MNAT CDK activating kinase assembly factor 1 antibody; Mnat1 antibody; p35 antibody; p36 antibody; RING finger protein 66 antibody; RING finger protein MAT1 antibody; RNF66 antibody; TFB3 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human CDK-activating kinase assembly factor MAT1 protein (1-309AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，MNAT1 Antibody (CSB-PA014686LA01HU)，的標(biāo)記方式是Non-conjugated。對于MNAT1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA014686LB01HU	MNAT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA014686LC01HU	MNAT1 Antibody, FITC conjugated
Biotin	CSB-PA014686LD01HU	MNAT1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
基因功能參考文獻(xiàn)：
1. Expressions of components of the CAK complex, CDK7, MAT1, and Cyclin H are elevated in breast cancer. PMID: 27301701
2. The intrinsically programmed MAT1 expression and fragmentation regulate granulopoiesis. PMID: 23765726
3. The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H. PMID: 12140753
4. Retinoid-induced G1 arrest and differentiation activation are associated with a switch to enzyme hypophosphorylation of retinoic acid receptor alpha. PMID: 12213824
5. interaction with MTA1 and role in regulating estrogen receptor transactivation functions PMID: 12527756
6. In response to ATRA, PML/RARalpha is dissociated from CAK, leading to MAT1 degradation, G1 arrest, and decreased CAK phosphorylation of PML/RARalpha PMID: 16935935
7. Retinoic-acid-induced RAR-CAK signaling events appear to proceed intrinsically during granulocytic development of normal primitive hematopoietic cells. ALDH-governed RA availability may mediate this process by initiating RAR-CAK signaling. PMID: 17628022
8. These results suggested that genetic variants in CAK genes, Cdk7, cyclin H, MAT1, might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins. PMID: 17707548
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亞細(xì)胞定位：

Nucleus.
組織特異性：

Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.
數(shù)據(jù)庫鏈接：

HGNC: 7181

OMIM: 602659

KEGG: hsa:4331

STRING: 9606.ENSP00000261245

UniGene: Hs.509523

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