MMS19 Antibody
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中文名稱：MMS19兔多克隆抗體
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貨號：CSB-PA014682GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MMS19
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別名：hMMS19 antibody; homolog of yeast MMS19 antibody; MET18 antibody; MET18 homolog antibody; MET18MMS19 nucleotide excision repair homolog (S. cerevisiae) antibody; mms19 antibody; MMS19 nucleotide excision repair protein homolog antibody; MMS19 nucleotide excision repair, S. cerevisiae, homolog of antibody; MMS19-like (MET18 homolog, S. cerevisiae) antibody; MMS19-like protein antibody; MMS19_HUMAN antibody; MMS19L antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MMS19
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur (Fe-S) cluster assembly into ERCC2/XPD. Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
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基因功能參考文獻：
- findings suggest that MMS19 plays an essential role in maintaining mitochondrial genome stability PMID: 29035693
- POLE1 is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. PMID: 27235625
- We therefore propose the expression level of MMS19 as a candidate predictive marker of ACT benefit in resected NSCLC patients. PMID: 27802208
- Suggest that MMS19 may be a potential new predictor of metastasis and chemoradiotherapy response in esophageal squamous cell carcinoma. PMID: 25892874
- MMS19L polymorphisms are associated with response to chemotherapy in osteosarcoma. PMID: 23886164
- Single nucleotide polymorphisms in the MMS19L gene is associated with bone malignant tumors. PMID: 23679317
- Polymorphisms in ERCC1, codon-118 and MMS19 genes are not associated with clinical response to platinum or survival. PMID: 23632208
- MMS19 interacts with target proteins. MIP18 has a role to bridge MMS19 and CIAO1. CIAO1 also binds IOP1. PMID: 23585563
- The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. PMID: 23150669
- study demonstrates MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1 and MIP18; cytoplasmic MMS19 also binds to multiple nuclear Fe-S proteins involved in DNA metabolism; propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair PMID: 22678361
- identified MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery; MMS19 functions as part of the CIA targeting complex that interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance PMID: 22678362
- Results indicate that the MMS19-XPD protein complex is required for proper chromosome segregation, an abnormality of which could contribute to the pathogenesis in some cases of xeroderma pigmentosum. PMID: 20797633
- Cloning of the human MMS19 genes and functional complementation in Saccharomyces cerevisiae PMID: 11328871
- MMS19 HEAT repeat domain is essential for MMS19 function in NER and transcription, while domains A and B, within MMS19 N-terminus, modulate the balance between DNA repair and transcription. PMID: 16797255
- Single nucleotide polymorphisms in MMS19L is associated with pancreatic cancer. PMID: 19318433
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亞細胞定位：Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
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蛋白家族：MET18/MMS19 family
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組織特異性：Ubiquitously expressed with higher expression in testis.
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數據庫鏈接：
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