MMP26 Antibody
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中文名稱：MMP26兔多克隆抗體
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貨號(hào)：CSB-PA283929
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規(guī)格：￥1100
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圖片：
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Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: 293T cells, Primary antibody: CSB-PA283929(MMP26 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：MMP26
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別名：MMP26 antibody; Matrix metalloproteinase-26 antibody; MMP-26 antibody; EC 3.4.24.- antibody; Endometase antibody; Matrilysin-2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthetic peptide of Human MMP26
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.
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基因功能參考文獻(xiàn)：
- MMP26 is overexpressed in prostatic neoplasms patients, and can serve as a serum disease biomarker. PMID: 29270749
- The luciferase report assay demonstrated that MMP26 is a target gene of miR-125b. And the expression profile of MMP26 showed an inverse relationship with miR-125b in vivo and in vitro. PMID: 27143441
- MMP26+CXCR4+ cells may be circulating tumor cells in hepatocellular carcinoma. PMID: 26279442
- We found that only inhibition of JNK significantly decreased the activation of MMP26 in response to FGF1 stimulation, suggesting that activation of FGFR1 signaling may activate JNK to activate MMP26 in non-small-cell lung cancer PMID: 25566961
- Overexpression of MMP26 in SW1353 cells increased cell invasiveness, while inhibition of MMP26 decreased cell invasiveness. PMID: 25262277
- The binding of MMP-26 to GDF15 was responsible for the processing and maturation of pro-GDF15, and the process was dependent on enzymatic activity of MMP-26. In human placental trophoblast cells, MMP-26 could facilitate the pro-apoptotic effect of GDF15. PMID: 25093616
- matrilysin-2 was an independent prognostic marker for patients with colorectal cancer PMID: 24318970
- These results demonstrate that the HOXA10-mediated expression of MMP-26 promotes embryo adhesion during the process of embryonic implantation. PMID: 24565841
- The MMP-26 promoter region contains a putative ER response element. PMID: 23754174
- expression of MMP-26 protein was predominantly located in pre- and early-invasive areas suggesting MMP-26 expression as an early event in promoting GM-CSF dependent tumor invasion. PMID: 23634280
- Molecular analyses showed significant downregulation of expression of MMP-26 (p=0.03), and significant 9.8-fold upregulation of TGF-beta (p=0.01) in more degenerated discs vs. healthier discs. PMID: 21945733
- MMP-26 plays an important role in local invasion at least in part through coordination with MMP-9. PMID: 21805034
- direct association observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-26. present results demonstrate important role of MMPs in development of SCCs of lower lip and tongue. PMID: 21255765
- MMP-26 expression may be associated with multiple human carcinomas. MMP-26 may also contribute to smooth muscle function in the human prostate and cardiovascular system. PMID: 19895737
- role of these proteins in the process of invasion and metastasis cannot be ruled out since their presence is more marked along the tumor invasion front compared to more central areas of squamous cell carcinoma of the tongue PMID: 20491537
- GnRH I and II could up-regulate MMP-26 expression through the JNK signaling pathway in human trophoblast-like/trophoblast cells. PMID: 20074375
- MMP-26 contributes to tumor cell invasion, migration and angiogenesis PMID: 19956866
- MMP-26 expression in stroma is associated with larger Merkel cell carcinoma with poor prognosis. PMID: 19921252
- can cleave all subclasses of igG at a specific conserved site PMID: 11841844
- role of histidine(81) in mechanism of activation PMID: 11889136
- Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin. PMID: 11931652
- substrate specificity and protein cleavage sites PMID: 12119297
- Details of cleavage of pro-MMP-9 by MMP-26, facilitating the efficient cleavage of fibronectin by MMP-9, and promoting invasiveness of ARCaP cells across fibronectin or type IV collagen PMID: 12586837
- Present throughout menstrual cycle. Elevated during early to mid-luteal phase. Elevations in users of levonorgestrel implants experiencing irregular uterine bleeding. Seems to play role in hormonal regulation and endometrial tissue remodeling. PMID: 12969699
- distinguish shallow, intermediate, and deep S1' pocket characteristics PMID: 14532275
- MMP-26 was colocalized with MMP-9, TIMP-2, and TIMP-4 in breast cancer cells. PMID: 14744773
- Results suggest a functional relationship between TIMP-4 mRNA and MMP-26 mRNA, and possibly a role in human implantation. PMID: 15273280
- Matrilysin-2 overexpression is associated with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma PMID: 15333466
- The expression patterns of MMP26 in human placenta suggests complicated roles for MMP26 during the processes of placentation and hematopoiesis PMID: 15601912
- During esophageal tumorigenesis, MMP-21 and MMP-26 have different, unique expression patterns. PMID: 16641547
- Maximal expression of MMP-26, in the early and mid-secretory phase suggests its role during implantation and results show it is stored in epithelial cells, is not released spontaneously, and is controlled by TIMP-4 in both stroma and uterine fluid. PMID: 16809379
- Results indicate that MMP-26 and TIMP-4 may play an integral role during the conversion of high-grade prostatic intraepithelial neoplasia to invasive cancer and may also serve as markers for early prostate cancer diagnosis. PMID: 16940965
- results suggest that MMP-21 and MMP-26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorde PMID: 16984259
- A human breast cancer cell linetransfected with wild-type MMP-26 cDNA showed a calcium-dependent invasive potential when compared with controls. PMID: 17176253
- The putative role of MMP-26 as a marker of metastasesin pancreatic cancer warrants further studies PMID: 17873896
- expression of transmembrane 4 superfamily member 4 (TM4SF4) and matrix metalloproteinase 26 (MMP26) was found to be significantly decreased during the implantation window in patients with polycystic ovary syndrome. PMID: 18765015
- MMP-26 may be served as a tumor marker in monitoring progression and predicting prognosis of non-small cell lung cancer. PMID: 19448419
- MMP-26 and MMP-9 may contribute to the more aggressive behavior of squamous cell carcinomas in organ transplant recipients PMID: 19674198
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亞細(xì)胞定位：Secreted, extracellular space, extracellular matrix.
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蛋白家族：Peptidase M10A family
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組織特異性：Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.
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