MFNG Antibody

中文名稱：

MFNG兔多克隆抗體
貨號：

CSB-PA013757LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA013757LA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MFNG Polyclonal antibody
Uniprot No.：

O00587
基因名：

MFNG
別名：

MFNG; Beta-1,3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Beta-1,3-N-acetylglucosaminyltransferase manic fringe protein (28-321AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，MFNG Antibody (CSB-PA013757LA01HU)，的標(biāo)記方式是Non-conjugated。對于MFNG Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA013757LB01HU	MFNG Antibody, HRP conjugated	ELISA
FITC	CSB-PA013757LC01HU	MFNG Antibody, FITC conjugated
Biotin	CSB-PA013757LD01HU	MFNG Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1.
基因功能參考文獻(xiàn)：
1. MFNG imposes a negative correlation between Jag1 and Notch, being high Jag1 in the absence of MFNG predictive of poor prognosis. PMID: 30065304
2. Mfng is an oncogene acting through Notch-mediated induction of Pik3cg. PMID: 25808869
3. down regulated in Papillomavirus-mediated cervical neoplasia. PMID: 15280477
亞細(xì)胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 31 family
數(shù)據(jù)庫鏈接：

HGNC: 7038

OMIM: 602577

KEGG: hsa:4242

STRING: 9606.ENSP00000349490

UniGene: Hs.517603

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